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    hpo-29 N-alpha-acetyltransferase 16, NatA auxiliary subunit [ Caenorhabditis elegans ]

    Gene ID: 175189, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hpo-29
    Official Full Name
    N-alpha-acetyltransferase 16, NatA auxiliary subunit
    Primary source
    WormBase:WBGene00021754
    Locus tag
    CELE_Y50D7A.4
    See related
    AllianceGenome:WB:WBGene00021754
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable acetyltransferase activator activity. Predicted to be part of NatA complex. Predicted to be active in cytoplasm. Is expressed in anal depressor muscle; body wall musculature; and nervous system. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 50. Orthologous to human NAA15 (N-alpha-acetyltransferase 15, NatA auxiliary subunit) and NAA16 (N-alpha-acetyltransferase 16, NatA auxiliary subunit). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See hpo-29 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    12
    Sequence:
    Chromosome: III; NC_003281.10 (235844..254383)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Kinesin-like protein klp-20 Neighboring gene DUF19 domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Protein kinase domain-containing protein;phosphorylase kinase Neighboring gene DNA 5'-3' helicase Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Autism-associated missense genetic variants impact locomotion and neurodevelopment in Caenorhabditis elegans. Wong WR, et al. Hum Mol Genet, 2019 Jul 1. PMID 31220273, Free PMC Article
    2. Germline Maintenance Through the Multifaceted Activities of GLH/Vasa in Caenorhabditis elegans P Granules. Marnik EA, et al. Genetics, 2019 Nov. PMID 31506335, Free PMC Article
    3. The conserved histone chaperone LIN-53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans. Müthel S, et al. Aging Cell, 2019 Dec. PMID 31397537, Free PMC Article
    4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables acetyltransferase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of NatA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    N-alpha-acetyltransferase 16, NatA auxiliary subunit
    NP_497180.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      235844..254383
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064779.5 → NP_497180.3  N-alpha-acetyltransferase 16, NatA auxiliary subunit [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497180.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8WTL6
      Conserved Domains (3) summary
      sd00006
      Location:54 → 81
      TPR; TPR repeat [structural motif]
      pfam12569
      Location:192 → 692
      NARP1; NMDA receptor-regulated protein 1
      pfam13414
      Location:54 → 118
      TPR_11; TPR repeat
    Nucleotide Protein
    Heading Accession and Version

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