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    scc-3 Cohesin subunit scc-3 [ Caenorhabditis elegans ]

    Gene ID: 179749, updated on 9-Dec-2024

    Summary

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    Official Symbol
    scc-3
    Official Full Name
    Cohesin subunit scc-3
    Primary source
    WormBase:WBGene00004738
    Locus tag
    CELE_F18E2.3
    See related
    AllianceGenome:WB:WBGene00004738
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA binding activity and chromatin binding activity. Involved in meiotic sister chromatid cohesion; nuclear division; and regulation of DNA damage checkpoint. Located in chromatin and condensed chromosome. Part of cohesin complex. Is expressed in gonad. Human ortholog(s) of this gene implicated in Holoprosencephaly 13, X-linked; Mullegama-Klein-Martinez syndrome; autosomal dominant intellectual developmental disorder 47; primary ovarian insufficiency 8; and spermatogenic failure 61. Orthologous to several human genes including STAG1 (STAG1 cohesin complex component) and STAG2 (STAG2 cohesin complex component). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See scc-3 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    6
    Sequence:
    Chromosome: V; NC_003283.11 (12763945..12767933)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene ABC transporter domain-containing protein Neighboring gene Serpentine Receptor, class T Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Loading of meiotic cohesin by SCC-2 is required for early processing of DSBs and for the DNA damage checkpoint. Lightfoot J, et al. Curr Biol, 2011 Sep 13. PMID 21856158
    2. Caenorhabditis elegans EVL-14/PDS-5 and SCC-3 are essential for sister chromatid cohesion in meiosis and mitosis. Wang F, et al. Mol Cell Biol, 2003 Nov. PMID 14560015, Free PMC Article
    3. Distinct developmental function of two Caenorhabditis elegans homologs of the cohesin subunit Scc1/Rad21. Mito Y, et al. Mol Biol Cell, 2003 Jun. PMID 12808038, Free PMC Article
    4. The Caenorhabditis elegans SCC-3 homologue is required for meiotic synapsis and for proper chromosome disjunction in mitosis and meiosis. Pasierbek P, et al. Exp Cell Res, 2003 Oct 1. PMID 14499625
    5. Condensin I protects meiotic cohesin from WAPL-1 mediated removal. Hernandez MR, et al. PLoS Genet, 2018 May. PMID 29768402, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that condensin I binds to WAPL-1 and counteracts WAPL-1-dependent cohesin removal.
      Title: Condensin I protects meiotic cohesin from WAPL-1 mediated removal.
    2. Cytological localization and the consequences of the lack of the protein indicate that C. elegans SCC-3 is essential for sister chromatid cohesion both in mitosis and in meiosis.
      Title: The Caenorhabditis elegans SCC-3 homologue is required for meiotic synapsis and for proper chromosome disjunction in mitosis and meiosis.
    3. These results indicate that EVL-14/PDS-5 and SCC-3 have functions in both mitosis and meiosis.
      Title: Caenorhabditis elegans EVL-14/PDS-5 and SCC-3 are essential for sister chromatid cohesion in meiosis and mitosis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair involved in meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic sister chromatid segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA damage checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sister chromatid cohesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cohesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cohesin complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in condensed chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cohesin subunit scc-3
    NP_506193.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      12763945..12767933
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073792.6 → NP_506193.1  Cohesin subunit scc-3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506193.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q19555
      Conserved Domains (1) summary
      pfam08514
      Location:184 → 286
      STAG; STAG domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q19555.1

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