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    prx-11 Peroxisomal biogenesis factor 11 [ Caenorhabditis elegans ]

    Gene ID: 353387, updated on 9-Dec-2024

    Summary

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    Official Symbol
    prx-11
    Official Full Name
    Peroxisomal biogenesis factor 11
    Primary source
    WormBase:WBGene00004196
    Locus tag
    CELE_C47B2.8
    See related
    AllianceGenome:WB:WBGene00004196
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in defense response to Gram-negative bacterium and innate immune response. Predicted to be located in membrane. Predicted to be active in peroxisomal membrane. Is expressed in head mesodermal cell; hypodermis; intestine; and rectal gland cell. Orthologous to human PEX11G (peroxisomal biogenesis factor 11 gamma). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See prx-11 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003279.8 (12971615..12972259)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Proteasome subunit beta Neighboring gene Eukaryotic translation initiation factor 6 Neighboring gene UDP-glucose 4-epimerase Neighboring gene Tr-type G domain-containing protein Neighboring gene RNA-binding S4 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Endocrine pheromones couple fat rationing to dauer diapause through HNF4α nuclear receptors. Gao C, et al. Sci China Life Sci, 2021 Dec. PMID 34755252
    2. Modeling human peroxisome biogenesis disorders in the nematode Caenorhabditis elegans. Thieringer H, et al. J Cell Sci, 2003 May 1. PMID 12665560
    3. Spatiotemporal contact between peroxisomes and lipid droplets regulates fasting-induced lipolysis via PEX5. Kong J, et al. Nat Commun, 2020 Jan 29. PMID 31996685, Free PMC Article
    4. New Roles for the Heterochronic Transcription Factor LIN-29 in Cuticle Maintenance and Lipid Metabolism at the Larval-to-Adult Transition in Caenorhabditis elegans. Abete-Luzi P, et al. Genetics, 2020 Mar. PMID 31974205, Free PMC Article
    5. Ethanol-response genes and their regulation analyzed by a microarray and comparative genomic approach in the nematode Caenorhabditis elegans. Kwon JY, et al. Genomics, 2004 Apr. PMID 15028283

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peroxisome fission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peroxisome fission IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peroxisome fission ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of peroxisome size ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in peroxisomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Peroxisomal biogenesis factor 11
    NP_493273.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      12971615..12972259
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060872.3 → NP_493273.1  Peroxisomal biogenesis factor 11 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493273.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O62103
      Conserved Domains (1) summary
      pfam05648
      Location:14 → 214
      PEX11; Peroxisomal biogenesis factor 11 (PEX11)
    Nucleotide Protein
    Heading Accession and Version

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