F35A5.1 Titin-like [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: F35A5.1
Official Full Name: Titin-like
Primary source: WormBase:WBGene00018024
Locus tag: CELE_F35A5.1
See related: AllianceGenome:WB:WBGene00018024
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in intermediate filament bundle assembly. Predicted to be located in neurofilament. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2CC; amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 1; and monoclonal gammopathy of uncertain significance. Orthologous to human NEFH (neurofilament heavy chain). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See F35A5.1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 7

Sequence:: Chromosome: X; NC_003284.9 (3807466..3816429)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F35A5.1 (e-PCR)
- UniSTS:306213

K03C7.1 (e-PCR)
- UniSTS:305662

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables structural constituent of cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in axon development	IEA Inferred from Electronic Annotation more info
involved_in intermediate filament bundle assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in postsynaptic intermediate filament cytoskeleton organization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in neurofilament	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Titin-like

NP_508662.4

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

3807466..3816429

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_076261.7 → NP_508662.4 Titin-like [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_508662.4

Status: REVIEWED

UniProtKB/TrEMBL

G4SGM2, Q20007

Conserved Domains (1) summary

PHA03247
Location:447 → 910

PHA03247; large tegument protein UL36; Provisional