dre-1 F-box domain-containing protein;F-box protein dre-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: dre-1
Official Full Name: F-box domain-containing protein;F-box protein dre-1
Primary source: WormBase:WBGene00001089
Locus tag: CELE_K04A8.6
See related: AllianceGenome:WB:WBGene00001089
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable zinc ion binding activity. Involved in several processes, including mesodermal cell migration; nematode larval development; and positive regulation of apoptotic process involved in development. Located in cytoplasm and nucleus. Is expressed in several structures, including P5.p hermaphrodite; alimentary muscle; hypodermis; nervous system; and reproductive system. Human ortholog(s) of this gene implicated in breast carcinoma and lung non-small cell carcinoma. Orthologous to human FBXO11 (F-box protein 11). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See dre-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 11

Sequence:: Chromosome: V; NC_003283.11 (6533614..6546491, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The roles of positive feedback loops involving blmp-1 and the degradation regulation of DRE-1 has been described.
Title: Noise propagation with interlinked feed-forward pathways.
Our data suggest evolutionary conservation of these interactions and underscore the importance of DRE-1/FBXO11-mediated BLMP-1/PRDI-BF1 degradation in cellular state transitions during metazoan development.
Title: BLMP-1/Blimp-1 regulates the spatiotemporal cell migration pattern in C. elegans.
DRE-1 functions in parallel to EGL-1, requires CED-9 for activity, and binds to CED-9, suggesting that DRE-1 promotes apoptosis by inactivating CED-9.
Title: Related F-box proteins control cell death in Caenorhabditis elegans and human lymphoma.
Three genes, T03G6.3, C46G7.2 and K04A8.6, coding for novel protein components of the Caenorhabditis elegans sarcomere, were studied
Title: Determination of the mobility of novel and established Caenorhabditis elegans sarcomeric proteins in vivo.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K04A8.6 (e-PCR)
- UniSTS:311397

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gonad development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mesodermal cell migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in molting cycle, collagen and cuticulin-based cuticle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process involved in development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of apoptotic process involved in development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of development, heterochronic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: F-box domain-containing protein;F-box protein dre-1

NP_001368566.1

Confirmed by transcript evidence

NP_001379860.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

6533614..6546491 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001392535.1 → NP_001379860.1 F-box protein dre-1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q94251

Conserved Domains (3) summary

pfam12937
Location:162 → 206

F-box-like

pfam13229
Location:674 → 832

Beta_helix; Right handed beta helix region

cl19744
Location:860 → 901

zf-UBR; Putative zinc finger in N-recognin (UBR box)
NM_001380672.1 → NP_001368566.1 F-box domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3AS68

Conserved Domains (3) summary

pfam12937
Location:248 → 292

F-box-like

pfam13229
Location:760 → 918

Beta_helix; Right handed beta helix region

cl19744
Location:946 → 987

zf-UBR; Putative zinc finger in N-recognin (UBR box)