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    ula-1 NEDD8-activating enzyme E1 regulatory subunit [ Caenorhabditis elegans ]

    Gene ID: 266650, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ula-1
    Official Full Name
    NEDD8-activating enzyme E1 regulatory subunit
    Primary source
    WormBase:WBGene00006735
    Locus tag
    CELE_C26E6.8
    See related
    AllianceGenome:WB:WBGene00006735
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable NEDD8 activating enzyme activity. Involved in negative regulation of DNA damage response, signal transduction by p53 class mediator. Predicted to be active in cytoplasm. Orthologous to human NAE1 (NEDD8 activating enzyme E1 subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ula-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    7
    Sequence:
    Chromosome: III; NC_003281.10 (4918277..4920321, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Conserved Edge Expressed protein Neighboring gene arginine--tRNA ligase;putative arginine--tRNA ligase, cytoplasmic Neighboring gene putative DNA-directed RNA polymerases I, II, and III subunit RPABC3 Neighboring gene Cobalamin adenosyltransferase-like domain-containing protein Neighboring gene Histone-lysine N-methyltransferase set-2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The NED-8 conjugating system in Caenorhabditis elegans is required for embryogenesis and terminal differentiation of the hypodermis. Jones D, et al. Dev Biol, 2000 Oct 1. PMID 10993680
    2. The SCF FSN-1 ubiquitin ligase controls germline apoptosis through CEP-1/p53 in C. elegans. Gao MX, et al. Cell Death Differ, 2008 Jun. PMID 18340346
    3. Using RNA interference to identify specific modifiers of a temperature-sensitive, embryonic-lethal mutation in the Caenorhabditis elegans ubiquitin-like Nedd8 protein modification pathway E1-activating gene rfl-1. Dorfman M, et al. Genetics, 2009 Aug. PMID 19528325, Free PMC Article
    4. Functional and phylogenetic analysis of the ubiquitylation system in Caenorhabditis elegans: ubiquitin-conjugating enzymes, ubiquitin-activating enzymes, and ubiquitin-like proteins. Jones D, et al. Genome Biol, 2002. PMID 11806825, Free PMC Article
    5. Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity. Ceron J, et al. BMC Dev Biol, 2007 Apr 6. PMID 17417969, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables NEDD8 activating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NEDD8 activating enzyme activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-like modifier activating enzyme activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein neddylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein neddylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    NEDD8-activating enzyme E1 regulatory subunit
    NP_001348740.1
    • Confirmed by transcript evidence
    NP_498037.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      4918277..4920321 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001361710.4 → NP_001348740.1  NEDD8-activating enzyme E1 regulatory subunit [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2K5ATU0
      Conserved Domains (2) summary
      cd01493
      Location:8 → 541
      APPBP1_RUB; Ubiquitin activating enzyme (E1) subunit APPBP1. APPBP1 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
      cl22428
      Location:443 → 541
      E1_enzyme_family; Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common ...

    2. NM_065636.5 → NP_498037.2  NEDD8-activating enzyme E1 regulatory subunit [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498037.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q18217
      Conserved Domains (3) summary
      COG0476
      Location:9 → 181
      ThiF; Molybdopterin or thiamine biosynthesis adenylyltransferase [Coenzyme transport and metabolism]
      cd01493
      Location:8 → 539
      APPBP1_RUB; Ubiquitin activating enzyme (E1) subunit APPBP1. APPBP1 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
      cl22428
      Location:441 → 539
      E1_enzyme_family; Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q18217.2

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