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    unc-57 Endophilin-A homolog [ Caenorhabditis elegans ]

    Gene ID: 172078, updated on 9-Dec-2024

    Summary

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    Official Symbol
    unc-57
    Official Full Name
    Endophilin-A homolog
    Primary source
    WormBase:WBGene00006791
    Locus tag
    CELE_T04D1.3
    See related
    AllianceGenome:WB:WBGene00006791
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in clathrin-dependent endocytosis and necroptotic process. Located in neuromuscular junction. Is expressed in several structures, including coelomocyte; hermaphrodite gonad; intestine; muscle cell; and nervous system. Human ortholog(s) of this gene implicated in acute myeloid leukemia and high grade glioma. Orthologous to human SH3GL1 (SH3 domain containing GRB2 like 1, endophilin A2); SH3GL2 (SH3 domain containing GRB2 like 2, endophilin A1); and SH3GL3 (SH3 domain containing GRB2 like 3, endophilin A3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See unc-57 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    6
    Sequence:
    Chromosome: I; NC_003279.8 (4675133..4679448)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene SCP domain-containing protein Neighboring gene Transcriptional regulator ATRX homolog Neighboring gene F-box domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Synaptojanin cooperates in vivo with endophilin through an unexpected mechanism. Dong Y, et al. Elife, 2015 Apr 28. PMID 25918845, Free PMC Article
    2. Endophilin A and B Join Forces With Clathrin to Mediate Synaptic Vesicle Recycling in Caenorhabditis elegans. Yu SC, et al. Front Mol Neurosci, 2018. PMID 29962934, Free PMC Article
    3. Endophilin is required for synaptic vesicle endocytosis by localizing synaptojanin. Schuske KR, et al. Neuron, 2003 Nov 13. PMID 14622579
    4. Polyunsaturated fatty acids influence synaptojanin localization to regulate synaptic vesicle recycling. Marza E, et al. Mol Biol Cell, 2008 Mar. PMID 18094048, Free PMC Article
    5. The C2H2 zinc-finger protein SYD-9 is a putative posttranscriptional regulator for synaptic transmission. Wang Y, et al. Proc Natl Acad Sci U S A, 2006 Jul 5. PMID 16803962, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in clathrin-dependent endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in necroptotic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in programmed cell death IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in synaptic vesicle uncoating IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in presynapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synaptic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Endophilin-A homolog
    NP_001040680.1
    • Confirmed by transcript evidence
    NP_001040681.1
    • Confirmed by transcript evidence
    NP_001122512.1
    • Confirmed by transcript evidence
    NP_001122513.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      4675133..4679448
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001129040.5 → NP_001122512.1  Endophilin-A homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122512.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B1V8A0
      Conserved Domains (2) summary
      cd07592
      Location:25 → 245
      BAR_Endophilin_A; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-A
      cd11803
      Location:321 → 375
      SH3_Endophilin_A; Src homology 3 domain of Endophilin-A

    2. NM_001129041.3 → NP_001122513.1  Endophilin-A homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122513.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A5A8Q9, A5A8R0, B1V8A0, O61843, Q6TM46
      Conserved Domains (2) summary
      cd07592
      Location:25 → 245
      BAR_Endophilin_A; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-A
      cd11803
      Location:323 → 377
      SH3_Endophilin_A; Src homology 3 domain of Endophilin-A

    3. NM_001047215.5 → NP_001040680.1  Endophilin-A homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001040680.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B1V8A0
      Conserved Domains (2) summary
      cd07592
      Location:25 → 245
      BAR_Endophilin_A; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-A
      cd11803
      Location:319 → 373
      SH3_Endophilin_A; Src homology 3 domain of Endophilin-A

    4. NM_001047216.3 → NP_001040681.1  Endophilin-A homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001040681.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B1V8A0
      Conserved Domains (1) summary
      cd11803
      Location:44 → 98
      SH3_Endophilin_A; Src homology 3 domain of Endophilin-A
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B1V8A0.1

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