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    sdpn-1 SH3 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 181058, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sdpn-1
    Official Full Name
    SH3 domain-containing protein
    Primary source
    WormBase:WBGene00018467
    Locus tag
    CELE_F45E1.7
    See related
    AllianceGenome:WB:WBGene00018467
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable phospholipid binding activity. Involved in endocytic recycling. Located in early endosome and recycling endosome membrane. Is expressed in intestine and pharynx. Used to study Huntington's disease and neurodegenerative disease. Orthologous to human PACSIN1 (protein kinase C and casein kinase substrate in neurons 1); PACSIN2 (protein kinase C and casein kinase substrate in neurons 2); and PACSIN3 (protein kinase C and casein kinase substrate in neurons 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See sdpn-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    11
    Sequence:
    Chromosome: X; NC_003284.9 (7988931..7998229, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Rhodanese domain-containing protein Neighboring gene Histone H3.3 type 1 Neighboring gene Phosphoglycolate phosphatase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene KfrA_N domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PACSIN1 is indispensable for amphisome-lysosome fusion during basal autophagy and subsets of selective autophagy. Oe Y, et al. PLoS Genet, 2022 Jun. PMID 35771772, Free PMC Article
    2. Syndapin/SDPN-1 is required for endocytic recycling and endosomal actin association in the C. elegans intestine. Gleason AM, et al. Mol Biol Cell, 2016 Sep 14. PMID 27630264, Free PMC Article
    3. Age-associated decline in RAB-10 efficacy impairs intestinal barrier integrity. Zhang J, et al. Nat Aging, 2023 Sep. PMID 37640905
    4. A novel requirement for C. elegans Alix/ALX-1 in RME-1-mediated membrane transport. Shi A, et al. Curr Biol, 2007 Nov 20. PMID 17997305, Free PMC Article
    5. Interactions between Rab and Arf GTPases regulate endosomal phosphatidylinositol-4,5-bisphosphate during endocytic recycling. Shi A, et al. Small GTPases, 2013 Apr-Jun. PMID 23392104, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytic recycling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in plasma membrane tubulation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in recycling endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in recycling endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    SH3 domain-containing protein
    NP_001367621.1
    • Confirmed by transcript evidence
    NP_001367622.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      7988931..7998229 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001381035.1 → NP_001367621.1  SH3 domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q09989
      Conserved Domains (2) summary
      cd07655
      Location:10 → 267
      F-BAR_PACSIN; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons (PACSIN) proteins
      cl17036
      Location:431 → 483
      SH3; Src Homology 3 domain superfamily

    2. NM_001381034.1 → NP_001367622.1  SH3 domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6AHQ8
      Conserved Domains (2) summary
      cd07655
      Location:16 → 273
      F-BAR_PACSIN; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons (PACSIN) proteins
      cl17036
      Location:437 → 489
      SH3; Src Homology 3 domain superfamily
    Nucleotide Protein
    Heading Accession and Version

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