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    epg-6 Ectopic P granules protein 6 [ Caenorhabditis elegans ]

    Gene ID: 189705, updated on 9-Dec-2024

    Summary

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    Official Symbol
    epg-6
    Official Full Name
    Ectopic P granules protein 6
    Primary source
    WormBase:WBGene00012641
    Locus tag
    CELE_Y39A1A.1
    See related
    AllianceGenome:WB:WBGene00012641
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables phosphatidylinositol phosphate binding activity. Involved in autophagosome assembly. Located in cytoplasm. Is expressed in several structures, including nervous system. Human ortholog(s) of this gene implicated in neurodegeneration with brain iron accumulation 5. Orthologous to several human genes including WDR45 (WD repeat domain 45). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See epg-6 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    4
    Sequence:
    Chromosome: III; NC_003281.10 (10596610..10600188, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ShKT domain-containing protein Neighboring gene rRNA methyltransferase 1, mitochondrial Neighboring gene Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) Neighboring gene Reverse transcriptase domain-containing protein Neighboring gene Rab5 GDP/GTP exchange factor Neighboring gene Secreted protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ATG-18 and EPG-6 are Both Required for Autophagy but Differentially Contribute to Lifespan Control in Caenorhabditis elegans. Takacs Z, et al. Cells, 2019 Mar 12. PMID 30871075, Free PMC Article
    2. WIPI-Mediated Autophagy and Longevity. Grimmel M, et al. Cells, 2015 May 22. PMID 26010754, Free PMC Article
    3. The WD40 repeat PtdIns(3)P-binding protein EPG-6 regulates progression of omegasomes to autophagosomes. Lu Q, et al. Dev Cell, 2011 Aug 16. PMID 21802374
    4. The two C. elegans ATG-16 homologs have partially redundant functions in the basal autophagy pathway. Zhang H, et al. Autophagy, 2013 Dec. PMID 24185444, Free PMC Article
    5. A conserved requirement for RME-8/DNAJC13 in neuronal autophagic lysosome reformation. Swords SB, et al. Autophagy, 2024 Apr. PMID 37942902, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3,5-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3,5-bisphosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol-3-phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol-4-phosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol-5-phosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in autophagosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in autophagy of mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in autophagy of peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein lipidation involved in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to phagophore assembly site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in phagophore assembly site membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in phagophore assembly site membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ectopic P granules protein 6
    NP_001255083.1
    • Confirmed by transcript evidence
    NP_001379429.1
    • Confirmed by transcript evidence
    NP_499335.2
    • Confirmed by transcript evidence
    NP_871659.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      10596610..10600188 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066934.5 → NP_499335.2  Ectopic P granules protein 6 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499335.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XX21
      Conserved Domains (2) summary
      COG2319
      Location:9 → 320
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:80 → 124
      7WD40; WD40 repeat [structural motif]

    2. NM_001392195.1 → NP_001379429.1  Ectopic P granules protein 6 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (2) summary
      COG2319
      Location:10 → 288
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:48 → 92
      7WD40; WD40 repeat [structural motif]

    3. NM_181930.8 → NP_871659.1  Ectopic P granules protein 6 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_871659.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      E3CTH5, Q5DTE8, Q86MP3, Q9XX21
      Conserved Domains (2) summary
      COG2319
      Location:9 → 320
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:80 → 124
      7WD40; WD40 repeat [structural motif]

    4. NM_001268154.3 → NP_001255083.1  Ectopic P granules protein 6 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255083.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E3CTH5
      Conserved Domains (2) summary
      COG2319
      Location:1 → 213
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:66 → 109
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86MP3.1

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