crn-4 3'-5' exonuclease crn-4 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: crn-4
Official Full Name: 3'-5' exonuclease crn-4
Primary source: WormBase:WBGene00000797
Locus tag: CELE_AH9.2
See related: AllianceGenome:WB:WBGene00000797
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables nuclease activity and single-stranded DNA binding activity. Involved in RNA catabolic process and apoptotic DNA fragmentation. Predicted to be active in cytoplasm. Orthologous to human ERI1 (exoribonuclease 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See crn-4 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 6

Sequence:: Chromosome: X; NC_003284.9 (2255848..2258101, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

crystal structure of CRN-4; a structural model is suggested where chromosomal DNA is bound at the Zn-domain and cleaved at the DEDDh nuclease domain in CRN-4 when the cell is undergoing apoptosis [CRN-4]
Title: Crystal structure of CRN-4: implications for domain function in apoptotic DNA degradation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AH9.2 (e-PCR)
- UniSTS:319881

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables 3'-5' exonuclease activity	IDA Inferred from Direct Assay more info	PubMed
enables 3'-5' exonuclease activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables 3'-5'-RNA exonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA endonuclease activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA nuclease activity	IDA Inferred from Direct Assay more info	PubMed
enables RNA nuclease activity	IDA Inferred from Direct Assay more info	PubMed
enables exonuclease activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables single-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in RNA catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in apoptotic DNA fragmentation	IDA Inferred from Direct Assay more info	PubMed
involved_in apoptotic DNA fragmentation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in apoptotic DNA fragmentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: 3'-5' exonuclease crn-4

NP_508415.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

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Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

2255848..2258101 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_076014.5 → NP_508415.1 3'-5' exonuclease crn-4 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_508415.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q10905

Conserved Domains (1) summary

cd06133
Location:11 → 196

ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins