U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    spd-3 Spindle defective protein 3 [ Caenorhabditis elegans ]

    Gene ID: 177438, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    spd-3
    Official Full Name
    Spindle defective protein 3
    Primary source
    WormBase:WBGene00004954
    Locus tag
    CELE_H34C03.1
    See related
    AllianceGenome:WB:WBGene00004954
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in several processes, including homologous chromosome segregation; microtubule cytoskeleton organization; and vulval development. Located in mitochondrion. [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See spd-3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    7
    Sequence:
    Chromosome: IV; NC_003282.8 (6762716..6765200)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Ubiquitin carboxyl-terminal hydrolase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Loss of the mitochondrial protein SPD-3 elevates PLK-1 levels and dysregulates mitotic events. Chen YZ, et al. Life Sci Alliance, 2023 Nov. PMID 37684042, Free PMC Article
    2. Chromosome movements promoted by the mitochondrial protein SPD-3 are required for homology search during Caenorhabditis elegans meiosis. Labrador L, et al. PLoS Genet, 2013 May. PMID 23671424, Free PMC Article
    3. A genetic screen for temperature-sensitive cell-division mutants of Caenorhabditis elegans. O'Connell KF, et al. Genetics, 1998 Jul. PMID 9649522, Free PMC Article
    4. SPD-3 is required for spindle alignment in Caenorhabditis elegans embryos and localizes to mitochondria. Dinkelmann MV, et al. Genetics, 2007 Nov. PMID 17947426, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of the mitochondrial protein SPD-3 elevates PLK-1 levels and dysregulates mitotic events.
      Title: Loss of the mitochondrial protein SPD-3 elevates PLK-1 levels and dysregulates mitotic events.
    2. SPD-3 is required for homology search at the start of meiosis
      Title: Chromosome movements promoted by the mitochondrial protein SPD-3 are required for homology search during Caenorhabditis elegans meiosis.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in chromosome localization to nuclear envelope involved in homologous chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in homologous chromosome pairing at meiosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vulval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Spindle defective protein 3
    NP_501036.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      6762716..6765200
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068635.7 → NP_501036.1  Spindle defective protein 3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501036.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9TYY7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9TYY7.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools