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    met-1 Histone-lysine N-methyltransferase [ Caenorhabditis elegans ]

    Gene ID: 172026, updated on 9-Dec-2024

    Summary

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    Official Symbol
    met-1
    Official Full Name
    Histone-lysine N-methyltransferase
    Primary source
    WormBase:WBGene00016603
    Locus tag
    CELE_C43E11.3
    See related
    AllianceGenome:WB:WBGene00016603
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables histone H3K36 methyltransferase activity. Involved in negative regulation of transcription by RNA polymerase II and negative regulation of vulval development. Predicted to be located in chromatin. Predicted to be active in nucleus. Is expressed in germ line; hypodermis; intestine; muscle cell; and neurons. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder; carcinoma (multiple); gastrointestinal system cancer (multiple); idiopathic pulmonary fibrosis; and malignant mesothelioma. Orthologous to human SETD2 (SET domain containing 2, histone lysine methyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See met-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    14
    Sequence:
    Chromosome: I; NC_003279.8 (4254197..4264699)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Conserved oligomeric Golgi complex subunit 5 Neighboring gene Transcription factor TFIIIC triple barrel domain-containing protein Neighboring gene Crossover junction endonuclease MUS81 Neighboring gene 60S ribosome subunit biogenesis protein NIP7 homolog Neighboring gene Cell division control protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An inverse relationship to germline transcription defines centromeric chromatin in C. elegans. Gassmann R, et al. Nature, 2012 Apr 8. PMID 22495302, Free PMC Article
    2. Trimethylation of Lys36 on H3 restricts gene expression change during aging and impacts life span. Pu M, et al. Genes Dev, 2015 Apr 1. PMID 25838541, Free PMC Article
    3. The histone H3K36 methyltransferase MES-4 acts epigenetically to transmit the memory of germline gene expression to progeny. Rechtsteiner A, et al. PLoS Genet, 2010 Sep 2. PMID 20824077, Free PMC Article
    4. MORC-1 Integrates Nuclear RNAi and Transgenerational Chromatin Architecture to Promote Germline Immortality. Weiser NE, et al. Dev Cell, 2017 May 22. PMID 28535375, Free PMC Article
    5. Histone methyltransferases MES-4 and MET-1 promote meiotic checkpoint activation in Caenorhabditis elegans. Lamelza P, et al. PLoS Genet, 2012. PMID 23166523, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We propose that MES-4 and MET-1 antagonize heterochromatin assembly at PCs of unsynapsed chromosomes by promoting a transcriptionally permissive chromatin environment that is required for meiotic checkpoint function
      Title: Histone methyltransferases MES-4 and MET-1 promote meiotic checkpoint activation in Caenorhabditis elegans.
    2. Two C. elegans histone methyltransferases repress lin-3 EGF transcription to inhibit vulval development.
      Title: Two C. elegans histone methyltransferases repress lin-3 EGF transcription to inhibit vulval development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables histone H3 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K36 methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H3K36 methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables histone methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-lysine N-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of vulval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Histone-lysine N-methyltransferase
    NP_491340.2
    • Confirmed by transcript evidence
    NP_871842.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      4254197..4264699
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_182042.4 → NP_871842.2  Histone-lysine N-methyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_871842.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4LBC3
      Conserved Domains (5) summary
      smart00570
      Location:623 → 668
      AWS; associated with SET domains
      smart00317
      Location:680 → 796
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      PHA03283
      Location:205 → 294
      PHA03283; envelope glycoprotein E; Provisional
      cd00201
      Location:1352 → 1379
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      TIGR02794
      Location:1286 → 1361
      tolA_full; TolA protein

    2. NM_058939.6 → NP_491340.2  Histone-lysine N-methyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491340.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4LBC2
      Conserved Domains (5) summary
      smart00570
      Location:637 → 682
      AWS; associated with SET domains
      smart00317
      Location:694 → 810
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      PHA03283
      Location:219 → 308
      PHA03283; envelope glycoprotein E; Provisional
      cd00201
      Location:1366 → 1393
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      TIGR02794
      Location:1300 → 1375
      tolA_full; TolA protein
    Nucleotide Protein
    Heading Accession and Version

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