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    smi-1 Gem-associated protein 2 [ Caenorhabditis elegans ]

    Gene ID: 189726, updated on 9-Dec-2024

    Summary

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    Official Symbol
    smi-1
    Official Full Name
    Gem-associated protein 2
    Primary source
    WormBase:WBGene00004886
    Locus tag
    CELE_Y39A3CR.1
    See related
    AllianceGenome:WB:WBGene00004886
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in embryo development. Located in cytoplasm. Is expressed in body wall musculature; intestine; and ventral cord neurons. Used to study spinal muscular atrophy. Orthologous to human GEMIN2 (gem nuclear organelle associated protein 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See smi-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    5
    Sequence:
    Chromosome: III; NC_003281.10 (1878365..1880866)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene TPR_REGION domain-containing protein;Tetratricopeptide repeat protein 7 N-terminal domain-containing protein Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene protein of unknown function WSN domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Caenorhabditis elegans in the study of SMN-interacting proteins: a role for SMI-1, an orthologue of human Gemin2 and the identification of novel components of the SMN complex. Burt EC, et al. Invert Neurosci, 2006 Dec. PMID 16964508
    2. PETISCO is a novel protein complex required for 21U RNA biogenesis and embryonic viability. Cordeiro Rodrigues RJ, et al. Genes Dev, 2019 Jul 1. PMID 31147388, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spliceosomal complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spliceosomal snRNP assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spliceosomal snRNP assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of SMN complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SMN complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Gem-associated protein 2
    NP_001022847.1
    • Confirmed by transcript evidence
    NP_001391141.1
    • Confirmed by transcript evidence
    NP_001391142.1
    • Confirmed by transcript evidence
    NP_001407507.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      1878365..1880866
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001027676.4 → NP_001022847.1  Gem-associated protein 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022847.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N405
      Conserved Domains (1) summary
      pfam04938
      Location:14 → 249
      SIP1; Survival motor neuron (SMN) interacting protein 1 (SIP1)

    2. NM_001420611.1 → NP_001407507.1  Gem-associated protein 2 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A8S4QGJ8

    3. NM_001404271.1 → NP_001391142.1  Gem-associated protein 2 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A8S4QAY3

    4. NM_001404272.1 → NP_001391141.1  Gem-associated protein 2 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A8S4Q9E8
    Nucleotide Protein
    Heading Accession and Version

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