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    cdc-6 Cell division control protein [ Caenorhabditis elegans ]

    Gene ID: 172029, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cdc-6
    Official Full Name
    Cell division control protein
    Primary source
    WormBase:WBGene00000382
    Locus tag
    CELE_C43E11.10
    See related
    AllianceGenome:WB:WBGene00000382
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA replication origin binding activity. Predicted to be involved in DNA replication initiation and mitotic DNA replication checkpoint signaling. Located in condensed nuclear chromosome; cytoplasm; and nucleolus. Is expressed in seam cell. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 5. Orthologous to human CDC6 (cell division cycle 6). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cdc-6 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    5
    Sequence:
    Chromosome: I; NC_003279.8 (4268070..4270287, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Histone-lysine N-methyltransferase Neighboring gene Crossover junction endonuclease MUS81 Neighboring gene 60S ribosome subunit biogenesis protein NIP7 homolog Neighboring gene SAP domain-containing protein Neighboring gene PEST proteolytic signal-containing nuclear protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. C. elegans CUL-4 prevents rereplication by promoting the nuclear export of CDC-6 via a CKI-1-dependent pathway. Kim J, et al. Curr Biol, 2007 Jun 5. PMID 17509881, Free PMC Article
    2. The dynamics of replication licensing in live Caenorhabditis elegans embryos. Sonneville R, et al. J Cell Biol, 2012 Jan 23. PMID 22249291, Free PMC Article
    3. PAR-4/LKB1 regulates DNA replication during asynchronous division of the early C. elegans embryo. Benkemoun L, et al. J Cell Biol, 2014 May 26. PMID 24841566, Free PMC Article
    4. CDC-48/p97 coordinates CDT-1 degradation with GINS chromatin dissociation to ensure faithful DNA replication. Franz A, et al. Mol Cell, 2011 Oct 7. PMID 21981920, Free PMC Article
    5. Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity. Ceron J, et al. BMC Dev Biol, 2007 Apr 6. PMID 17417969, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA replication origin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic DNA replication checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in condensed nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cell division control protein
    NP_491343.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      4268070..4270287 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058942.8 → NP_491343.1  Cell division control protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491343.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      P91155
      Conserved Domains (2) summary
      smart00382
      Location:197 → 335
      AAA; ATPases associated with a variety of cellular activities
      pfam13401
      Location:197 → 279
      AAA_22; AAA domain
    Nucleotide Protein
    Heading Accession and Version

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