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    Y71F9AL.10 RING-type E3 ubiquitin transferase [ Caenorhabditis elegans ]

    Gene ID: 171852, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Y71F9AL.10
    Official Full Name
    RING-type E3 ubiquitin transferase
    Primary source
    WormBase:WBGene00022115
    Locus tag
    CELE_Y71F9AL.10
    See related
    AllianceGenome:WB:WBGene00022115
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein K48-linked ubiquitination. Predicted to be located in lysosome. Predicted to be active in cytoplasm; intracellular membrane-bounded organelle; and membrane. Orthologous to human ZNRF1 (zinc and ring finger 1) and ZNRF2 (zinc and ring finger 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See Y71F9AL.10 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    6
    Sequence:
    Chromosome: I; NC_003279.8 (2866506..2870172)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Plasma membrane proteolipid 3 Neighboring gene ncRNA Neighboring gene DUF3306 domain-containing protein;Increased recombination centers protein 6;Pre-rRNA-processing protein TSR2 homolog;UAE_UbL domain-containing protein Neighboring gene Large ribosomal subunit protein uL1 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. C. elegans ORFeome version 1.1: experimental verification of the genome annotation and resource for proteome-scale protein expression. Reboul J, et al. Nat Genet, 2003 May. PMID 12679813
    2. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K48-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RING-type E3 ubiquitin transferase
    NP_001360588.1
    • Confirmed by transcript evidence
    NP_001360589.1
    • Confirmed by transcript evidence
    NP_001360590.1
    • Confirmed by transcript evidence
    NP_001360591.1
    • Confirmed by transcript evidence
    NP_491059.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      2866506..2870172
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001373751.2 → NP_001360588.1  RING-type E3 ubiquitin transferase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0IMW1
      Conserved Domains (1) summary
      cd16489
      Location:123 → 165
      mRING-CH-C4HC2H_ZNRF; Modified RING-CH finger, H2 subclass (C4HC2H-type), found in the ZNRF family

    2. NM_001373752.1 → NP_001360589.1  RING-type E3 ubiquitin transferase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0IMP7
      Conserved Domains (1) summary
      cd16489
      Location:142 → 184
      mRING-CH-C4HC2H_ZNRF; Modified RING-CH finger, H2 subclass (C4HC2H-type), found in the ZNRF family

    3. NM_001373753.3 → NP_001360590.1  RING-type E3 ubiquitin transferase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V6Z7Z0
      Conserved Domains (1) summary
      cd16489
      Location:121 → 163
      mRING-CH-C4HC2H_ZNRF; Modified RING-CH finger, H2 subclass (C4HC2H-type), found in the ZNRF family

    4. NM_058658.9 → NP_491059.2  RING-type E3 ubiquitin transferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491059.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N4I6
      Conserved Domains (1) summary
      cd16489
      Location:144 → 186
      mRING-CH-C4HC2H_ZNRF; Modified RING-CH finger, H2 subclass (C4HC2H-type), found in the ZNRF family

    5. NM_001373757.2 → NP_001360591.1  RING-type E3 ubiquitin transferase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0IJT2
      Conserved Domains (1) summary
      cd16489
      Location:107 → 149
      mRING-CH-C4HC2H_ZNRF; Modified RING-CH finger, H2 subclass (C4HC2H-type), found in the ZNRF family
    Nucleotide Protein
    Heading Accession and Version

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