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    crn-6 Cell death-related nuclease 6 [ Caenorhabditis elegans ]

    Gene ID: 176316, updated on 9-Dec-2024

    Summary

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    Official Symbol
    crn-6
    Official Full Name
    Cell death-related nuclease 6
    Primary source
    WormBase:WBGene00000799
    Locus tag
    CELE_K04H4.6
    See related
    AllianceGenome:WB:WBGene00000799
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables deoxyribonuclease II activity. Involved in apoptotic DNA fragmentation. Is expressed in intestinal cell and seam cell. Orthologous to human DNASE2B (deoxyribonuclease 2 beta). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See crn-6 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    10
    Sequence:
    Chromosome: III; NC_003281.10 (9367271..9370381)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene FMRF-Like Peptide Neighboring gene Uncharacterized protein Neighboring gene putative G-protein coupled receptor tkr-1 Neighboring gene putative transporter slc-17.2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Autonomous and non-autonomous roles of DNase II during cell death in C. elegans embryos. Yu H, et al. Biosci Rep, 2015 Apr 27. PMID 26182365, Free PMC Article
    2. The roles and acting mechanism of Caenorhabditis elegans DNase II genes in apoptotic dna degradation and development. Lai HJ, et al. PLoS One, 2009 Oct 7. PMID 19809494, Free PMC Article
    3. Loss of DNase II function in the gonad is associated with a higher expression of antimicrobial genes in Caenorhabditis elegans. Yu H, et al. Biochem J, 2015 Aug 15. PMID 26251453
    4. Functional genomic analysis of apoptotic DNA degradation in C. elegans. Parrish JZ, et al. Mol Cell, 2003 Apr. PMID 12718884
    5. Programmed cell death. Conradt B, et al. WormBook, 2005 Oct 6. PMID 18061982, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables deoxyribonuclease II activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables deoxyribonuclease II activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables deoxyribonuclease II activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in apoptotic DNA fragmentation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in apoptotic DNA fragmentation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in apoptotic DNA fragmentation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cell death-related nuclease 6
    NP_001370104.1
    • Confirmed by transcript evidence
    NP_499061.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      9367271..9370381
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066660.6 → NP_499061.2  Cell death-related nuclease 6 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499061.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34508, Q9NAQ0, Q9NCF8
      Conserved Domains (3) summary
      cd09120
      Location:17 → 161
      PLDc_DNaseII_1; Catalytic domain, repeat 1, of Deoxyribonuclease II and similar proteins
      cd09121
      Location:208 → 356
      PLDc_DNaseII_2; Catalytic domain, repeat 2, of Deoxyribonuclease II and similar proteins
      pfam03265
      Location:20 → 352
      DNase_II; Deoxyribonuclease II

    2. NM_001382961.2 → NP_001370104.1  Cell death-related nuclease 6 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      pfam03265
      Location:22 → 343
      DNase_II; Deoxyribonuclease II
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34508.3

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