vha-8 V-type proton ATPase subunit E [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: vha-8
Official Full Name: V-type proton ATPase subunit E
Primary source: WormBase:WBGene00006917
Locus tag: CELE_C17H12.14
See related: AllianceGenome:WB:WBGene00006917
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in proton transmembrane transport. Located in apical plasma membrane and cytoplasm. Is expressed in several structures, including excretory cell; head; hypodermis; intestine; and vulval muscle. Human ortholog(s) of this gene implicated in autosomal recessive cutis laxa type IIC. Orthologous to several human genes including ATP6V1E2 (ATPase H+ transporting V1 subunit E2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See vha-8 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 4

Sequence:: Chromosome: IV; NC_003282.8 (6791074..6792455)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Caenorhabditis elegans vha-8 encodes the E subunit of V-ATPase which is expressed in the hypodermis, intestine and H-shaped excretory cells.
Title: VHA-8, the E subunit of V-ATPase, is essential for pH homeostasis and larval development in C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C17H12.14 (e-PCR)
- UniSTS:321670

STS4-139 (e-PCR)
- UniSTS:242128

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables proton-transporting ATPase activity, rotational mechanism	IBA Inferred from Biological aspect of Ancestor more info
enables proton-transporting ATPase activity, rotational mechanism	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of proton-transporting two-sector ATPase complex, catalytic domain	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: V-type proton ATPase subunit E

NP_501040.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

6791074..6792455

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_068639.8 → NP_501040.1 V-type proton ATPase subunit E [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_501040.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q95X44

Conserved Domains (2) summary

COG1390
Location:9 → 218

NtpE; Archaeal/vacuolar-type H+-ATPase subunit E/Vma4 [Energy production and conversion]

pfam01991
Location:18 → 216

vATP-synt_E; ATP synthase (E/31 kDa) subunit