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    lin-61 Protein lin-61 [ Caenorhabditis elegans ]

    Gene ID: 172467, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lin-61
    Official Full Name
    Protein lin-61
    Primary source
    WormBase:WBGene00003041
    Locus tag
    CELE_R06C7.7
    See related
    AllianceGenome:WB:WBGene00003041
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable chromatin binding activity and methylated histone binding activity. Involved in vulval development. Located in chromatin and nucleus. Is expressed widely. Orthologous to several human genes including L3MBTL2 (L3MBTL histone methyl-lysine binding protein 2) and MBTD1 (mbt domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lin-61 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    7
    Sequence:
    Chromosome: I; NC_003279.8 (7248827..7251282, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Chondroitin proteoglycan 3 Neighboring gene Protein N-terminal glutamine amidohydrolase Neighboring gene Adenylosuccinate lyase Neighboring gene Mitotic checkpoint serine/threonine-protein kinase bub-1 Neighboring gene C2H2-type domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A role for the malignant brain tumour (MBT) domain protein LIN-61 in DNA double-strand break repair by homologous recombination. Johnson NM, et al. PLoS Genet, 2013. PMID 23505385, Free PMC Article
    2. SETDB1-like MET-2 promotes transcriptional silencing and development independently of its H3K9me-associated catalytic activity. Delaney CE, et al. Nat Struct Mol Biol, 2022 Feb. PMID 35102319, Free PMC Article
    3. A team of heterochromatin factors collaborates with small RNA pathways to combat repetitive elements and germline stress. McMurchy AN, et al. Elife, 2017 Mar 15. PMID 28294943, Free PMC Article
    4. A Forward Genetic Screen for Suppressors of Somatic P Granules in Caenorhabditis elegans. Kelly AL, et al. G3 (Bethesda), 2015 Jun 22. PMID 26100681, Free PMC Article
    5. Reevaluation of whether a soma-to-germ-line transformation extends lifespan in Caenorhabditis elegans. Knutson AK, et al. Proc Natl Acad Sci U S A, 2016 Mar 29. PMID 26976573, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Argonaute NRDE-3 and MBT domain protein LIN-61 redundantly recruit an H3K9me3 HMT to prevent embryonic lethality and transposon expression.
      Title: Argonaute NRDE-3 and MBT domain protein LIN-61 redundantly recruit an H3K9me3 HMT to prevent embryonic lethality and transposon expression.
    2. Using a novel reporter system that monitors repair of a defined DSB in C. elegans somatic cells, we show that LIN-61 contributes to homologous recombination .
      Title: A role for the malignant brain tumour (MBT) domain protein LIN-61 in DNA double-strand break repair by homologous recombination.
    3. H3K9me2/3 interaction of LIN-61 is required for C. elegans vulva development within the synMuvB pathway
      Title: H3K9me2/3 binding of the MBT domain protein LIN-61 is essential for Caenorhabditis elegans vulva development.
    4. These data indicate that while the class B synMuv genes act together to regulate vulval development, lin-61 functions separately from some class B synMuv proteins in other biological processes.
      Title: LIN-61, one of two Caenorhabditis elegans malignant-brain-tumor-repeat-containing proteins, acts with the DRM and NuRD-like protein complexes in vulval development but not in certain other biological processes.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vulval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Protein lin-61
    NP_001122501.1
    • Confirmed by transcript evidence
    NP_492050.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      7248827..7251282 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059649.6 → NP_492050.3  Protein lin-61 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492050.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B2D6M2
      Conserved Domains (2) summary
      smart00561
      Location:390 → 486
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      pfam02820
      Location:312 → 384
      MBT; mbt repeat

    2. NM_001129029.3 → NP_001122501.1  Protein lin-61 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122501.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B2D6M2, Q21769
      Conserved Domains (2) summary
      smart00561
      Location:511 → 607
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      pfam02820
      Location:433 → 505
      MBT; mbt repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B2D6M2.1

    Gene LinkOut

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