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    smg-7 DNA/RNA-binding domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 177435, updated on 9-Dec-2024

    Summary

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    Official Symbol
    smg-7
    Official Full Name
    DNA/RNA-binding domain-containing protein
    Primary source
    WormBase:WBGene00004885
    Locus tag
    CELE_Y73B6A.4
    See related
    AllianceGenome:WB:WBGene00004885
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable telomerase RNA binding activity and telomeric DNA binding activity. Involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Located in cytoplasm and nucleus. Orthologous to human SMG7 (SMG7 nonsense mediated mRNA decay factor). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See smg-7 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    7
    Sequence:
    Chromosome: IV; NC_003282.8 (6740531..6742443, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene TransThyretin-Related family domain Neighboring gene ncRNA Neighboring gene Raf homolog serine/threonine-protein kinase;non-specific serine/threonine protein kinase Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Global analysis of alternative splicing uncovers developmental regulation of nonsense-mediated decay in C. elegans. Barberan-Soler S, et al. RNA, 2009 Sep. PMID 19617316, Free PMC Article
    2. An unusual arrangement of two 14-3-3-like domains in the SMG5-SMG7 heterodimer is required for efficient nonsense-mediated mRNA decay. Jonas S, et al. Genes Dev, 2013 Jan 15. PMID 23348841, Free PMC Article
    3. A differential cytolocalization assay for analysis of macromolecular assemblies in the eukaryotic cytoplasm. Blanchard D, et al. Mol Cell Proteomics, 2006 Nov. PMID 16914455
    4. SMG-2 is a phosphorylated protein required for mRNA surveillance in Caenorhabditis elegans and related to Upf1p of yeast. Page MF, et al. Mol Cell Biol, 1999 Sep. PMID 10454541, Free PMC Article
    5. smg-7 is required for mRNA surveillance in Caenorhabditis elegans. Cali BM, et al. Genetics, 1999 Feb. PMID 9927455, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables telomerase RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables telomeric DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of telomerase holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DNA/RNA-binding domain-containing protein
    NP_501033.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      6740531..6742443 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068632.6 → NP_501033.1  DNA/RNA-binding domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501033.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EF47
      Conserved Domains (3) summary
      sd00006
      Location:130 → 158
      TPR; TPR repeat [structural motif]
      pfam07719
      Location:130 → 163
      TPR_2; Tetratricopeptide repeat
      pfam10373
      Location:149 → 249
      EST1_DNA_bind; Est1 DNA/RNA binding domain
    Nucleotide Protein
    Heading Accession and Version

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