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    aph-2 Nicastrin [ Caenorhabditis elegans ]

    Gene ID: 172905, updated on 9-Dec-2024

    Summary

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    Official Symbol
    aph-2
    Official Full Name
    Nicastrin
    Primary source
    WormBase:WBGene00000148
    Locus tag
    CELE_ZC434.6
    See related
    AllianceGenome:WB:WBGene00000148
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in several processes, including Notch signaling pathway; egg-laying behavior; and pharynx development. Located in plasma membrane. Is expressed in oocyte. Human ortholog(s) of this gene implicated in Alzheimer's disease; hidradenitis suppurativa; and schizophrenia. Orthologous to human NCSTN (nicastrin). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See aph-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    8
    Sequence:
    Chromosome: I; NC_003279.8 (10340997..10345654)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene DUF3421 domain-containing protein Neighboring gene DUF3421 domain-containing protein Neighboring gene glutamate--tRNA ligase Neighboring gene Cytochrome c oxidase assembly factor 6 homolog;PRORP domain-containing protein Neighboring gene putative arginine kinase ZC434.8 Neighboring gene ShKT domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. APH-2/nicastrin functions in LIN-12/Notch signaling in the Caenorhabditis elegans somatic gonad. Levitan D, et al. Dev Biol, 2001 Dec 15. PMID 11784090
    2. aph-2 encodes a novel extracellular protein required for GLP-1-mediated signaling. Goutte C, et al. Development, 2000 Jun. PMID 10804188
    3. Notch signaling without the APH-2/nicastrin subunit of gamma secretase in Caenorhabditis elegans germline stem cells. Brinkley DM, et al. Genetics, 2024 Jul 8. PMID 38717968
    4. MEX-3 is a KH domain protein that regulates blastomere identity in early C. elegans embryos. Draper BW, et al. Cell, 1996 Oct 18. PMID 8861905
    5. Genetics leads the way to the accomplices of presenilins. Goutte C. Dev Cell, 2002 Jul. PMID 12110162

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Notch signaling without the APH-2/nicastrin subunit of gamma secretase in Caenorhabditis elegans germline stem cells.
      Title: Notch signaling without the APH-2/nicastrin subunit of gamma secretase in Caenorhabditis elegans germline stem cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in Notch receptor processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell fate commitment involved in pattern specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in egg-laying behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryonic morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pharynx development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of gamma-secretase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nicastrin
    NP_001122563.1
    • Confirmed by transcript evidence
    NP_492712.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      10340997..10345654
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060311.4 → NP_492712.2  Nicastrin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492712.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q23316
      Conserved Domains (1) summary
      cd03881
      Location:171 → 500
      M28_Nicastrin; M28 Zn-Peptidase Nicastrin, a main component of gamma-secretase complex

    2. NM_001129091.3 → NP_001122563.1  Nicastrin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122563.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A5Z2T7
      Conserved Domains (1) summary
      cd03881
      Location:37 → 665
      M28_Nicastrin; M28 Zn-peptidase nicastrin, a main component of gamma-secretase complex
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q23316.3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.