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    epg-7 Autophagy-related protein 11 C-terminal domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 180996, updated on 9-Dec-2024

    Summary

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    Official Symbol
    epg-7
    Official Full Name
    Autophagy-related protein 11 C-terminal domain-containing protein
    Primary source
    WormBase:WBGene00020334
    Locus tag
    CELE_T08A9.1
    See related
    AllianceGenome:WB:WBGene00020334
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables molecular adaptor activity. Involved in positive regulation of macroautophagy. Located in cytoplasm. Is expressed in neurons; pharyngeal muscle cell; and tail. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human RB1CC1 (RB1 inducible coiled-coil 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See epg-7 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    14
    Sequence:
    Chromosome: X; NC_003284.9 (7334714..7340268)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Transthyretin-like family protein Neighboring gene TransThyretin-Related family domain Neighboring gene NADP-dependent oxidoreductase domain-containing protein Neighboring gene NADP-dependent oxidoreductase domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ALLO-1- and IKKE-1-dependent positive feedback mechanism promotes the initiation of paternal mitochondrial autophagy. Sasaki T, et al. Nat Commun, 2024 Feb 17. PMID 38368448, Free PMC Article
    2. The autophagy receptor ALLO-1 and the IKKE-1 kinase control clearance of paternal mitochondria in Caenorhabditis elegans. Sato M, et al. Nat Cell Biol, 2018 Jan. PMID 29255173
    3. The composition of a protein aggregate modulates the specificity and efficiency of its autophagic degradation. Zhang G, et al. Autophagy, 2017 Sep 2. PMID 28806108, Free PMC Article
    4. Autophagy and beyond: Unraveling the complexity of UNC-51-like kinase 1 (ULK1) from biological functions to therapeutic implications. Zou L, et al. Acta Pharm Sin B, 2022 Oct. PMID 36213540, Free PMC Article
    5. Inositol Polyphosphate Multikinase Inhibits Liquid-Liquid Phase Separation of TFEB to Negatively Regulate Autophagy Activity. Chen D, et al. Dev Cell, 2020 Dec 7. PMID 33290695

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular adaptor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in autophagosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in autophagy of mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in organelle organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pexophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in piecemeal microautophagy of the nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of macroautophagy IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in reticulophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Atg1/ULK1 kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in phagophore assembly site membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Autophagy-related protein 11 C-terminal domain-containing protein
    NP_509241.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      7334714..7340268
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076840.8 → NP_509241.2  Autophagy-related protein 11 C-terminal domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q22342
      Conserved Domains (3) summary
      TIGR02169
      Location:753 → 953
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam10377
      Location:1233 → 1322
      ATG11; Autophagy-related protein 11
      cl28922
      Location:3 → 78
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    Nucleotide Protein
    Heading Accession and Version

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