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    ampd-1 AMP deaminase [ Caenorhabditis elegans ]

    Gene ID: 173891, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ampd-1
    Official Full Name
    AMP deaminase
    Primary source
    WormBase:WBGene00016415
    Locus tag
    CELE_C34F11.3
    See related
    AllianceGenome:WB:WBGene00016415
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable AMP deaminase activity. Predicted to be involved in AMP metabolic process and IMP biosynthetic process. Predicted to be active in cytosol. Is expressed in several structures, including anal depressor muscle; hypodermis; nervous system; pharyngeal-intestinal valve; and reproductive system. Human ortholog(s) of this gene implicated in congestive heart failure; coronary artery disease; hereditary spastic paraplegia 63; and pontocerebellar hypoplasia type 9. Orthologous to several human genes including AMPD2 (adenosine monophosphate deaminase 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ampd-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    21
    Sequence:
    Chromosome: II; NC_003280.10 (5203322..5209801)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Tyrosine-protein kinase Neighboring gene Major sperm protein 19/31/40/45/50/51/53/59/61/65/81/113/142 Neighboring gene Glycine-rich protein Neighboring gene DUF4440 domain-containing protein Neighboring gene RING-type domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
    2. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
    3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    4. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables AMP deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables AMP deaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in AMP metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in IMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in IMP salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    AMP deaminase
    NP_001040752.2
    • Confirmed by transcript evidence
    NP_001343751.1
    • Partially confirmed by transcript evidence
    NP_494973.3
    • Confirmed by transcript evidence
    NP_494974.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      5203322..5209801
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_062573.6 → NP_494974.3  AMP deaminase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_494974.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KZ18
      Conserved Domains (2) summary
      PLN03055
      Location:159 → 777
      PLN03055; AMP deaminase; Provisional
      TIGR01429
      Location:162 → 775
      AMP_deaminase; AMP deaminase

    2. NM_001047287.5 → NP_001040752.2  AMP deaminase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001040752.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KZ19
      Conserved Domains (2) summary
      PLN03055
      Location:222 → 840
      PLN03055; AMP deaminase; Provisional
      TIGR01429
      Location:225 → 838
      AMP_deaminase; AMP deaminase

    3. NM_062572.7 → NP_494973.3  AMP deaminase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_494973.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      D7SFL2
      Conserved Domains (2) summary
      PLN03055
      Location:243 → 815
      PLN03055; AMP deaminase; Provisional
      TIGR01429
      Location:186 → 813
      AMP_deaminase; AMP deaminase

    4. NM_001356832.3 → NP_001343751.1  AMP deaminase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2C9C377
      Conserved Domains (1) summary
      TIGR01429
      Location:312 → 939
      AMP_deaminase; AMP deaminase
    Nucleotide Protein
    Heading Accession and Version

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