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    ocr-1 ANK_REP_REGION domain-containing protein;Ion transport domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 185101, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ocr-1
    Official Full Name
    ANK_REP_REGION domain-containing protein;Ion transport domain-containing protein
    Primary source
    WormBase:WBGene00003838
    Locus tag
    CELE_F28H7.10
    See related
    AllianceGenome:WB:WBGene00003838
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables temperature-gated cation channel activity. Involved in heat acclimation. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in ADLL; ADLR; AWAL; and AWAR. Human ortholog(s) of this gene implicated in several diseases, including colorectal cancer; congenital stationary night blindness; hyperparathyroidism; keratosis (multiple); and migraine with aura. Orthologous to several human genes including TRPV5 (transient receptor potential cation channel subfamily V member 5) and TRPV6 (transient receptor potential cation channel subfamily V member 6). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ocr-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    14
    Sequence:
    Chromosome: V; NC_003283.11 (10764366..10768590)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Receptor L-domain domain-containing protein Neighboring gene CRAL-TRIO domain-containing protein F28H7.8 Neighboring gene Serpentine receptor class epsilon-6 Neighboring gene ncRNA Neighboring gene PNPLA domain-containing protein Neighboring gene Proteasome subunit alpha type-2 Neighboring gene SGS domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. OSM-9 and OCR-2 TRPV channels are accessorial warm receptors in Caenorhabditis elegans temperature acclimatisation. Ohnishi K, et al. Sci Rep, 2020 Oct 29. PMID 33122746, Free PMC Article
    2. Cold acclimation via the KQT-2 potassium channel is modulated by oxygen in Caenorhabditis elegans. Okahata M, et al. Sci Adv, 2019 Feb. PMID 30775442, Free PMC Article
    3. A specific subset of transient receptor potential vanilloid-type channel subunits in Caenorhabditis elegans endocrine cells function as mixed heteromers to promote neurotransmitter release. Jose AM, et al. Genetics, 2007 Jan. PMID 17057248, Free PMC Article
    4. Function and regulation of TRP family channels in C. elegans. Xiao R, et al. Pflugers Arch, 2009 Sep. PMID 19421772, Free PMC Article
    5. Combinatorial expression of TRPV channel proteins defines their sensory functions and subcellular localization in C. elegans neurons. Tobin DM, et al. Neuron, 2002 Jul 18. PMID 12160748

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables temperature-gated cation channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heat acclimation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in heat acclimation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ANK_REP_REGION domain-containing protein;Ion transport domain-containing protein
    NP_001041107.1
    • Confirmed by transcript evidence
    NP_001335506.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      10764366..10768590
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001348583.2 → NP_001335506.1  Ion transport domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EDR9
      Conserved Domains (3) summary
      TIGR00870
      Location:154 → 756
      trp; transient-receptor-potential calcium channel protein
      sd00045
      Location:200 → 266
      ANK; ANK repeat [structural motif]
      pfam05672
      Location:781 → 849
      MAP7; MAP7 (E-MAP-115) family

    2. NM_001047642.1 → NP_001041107.1  ANK_REP_REGION domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001041107.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q1NZ21
    Nucleotide Protein
    Heading Accession and Version

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