mut-7 Exonuclease mut-7 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mut-7
Official Full Name: Exonuclease mut-7
Primary source: WormBase:WBGene00003504
Locus tag: CELE_ZK1098.8
See related: AllianceGenome:WB:WBGene00003504
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable 3'-5'-exoribonuclease activity involved in mature miRNA 3'-end processing. Involved in olfactory learning and regulatory ncRNA-mediated post-transcriptional gene silencing. Located in cytosol; mutator focus; and nucleus. Is expressed in several structures, including head neurons; intestine; rectal gland cell; reproductive system; and somatic cell. Orthologous to human EXD3 (exonuclease 3'-5' domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See mut-7 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 8

Sequence:: Chromosome: III; NC_003281.10 (9539031..9542380, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MUT-7 exoribonuclease activity and localization are mediated by an ancient domain.
Title: MUT-7 exoribonuclease activity and localization are mediated by an ancient domain.
MUT-7 Provides Molecular Insight into the Werner Syndrome Exonuclease.
Title: MUT-7 Provides Molecular Insight into the Werner Syndrome Exonuclease.
RNA interference proteins and MUT-7/RDE-2 function together in parallel pathways and/or as multiprotein complexes.
Title: Caenorhabditis elegans ABCRNAi transporters interact genetically with rde-2 and mut-7.
Interaction between RDE-2 and MUT-7 is required for efficient RNA interference.
Title: RDE-2 interacts with MUT-7 to mediate RNA interference in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZK1098.8 (e-PCR)
- UniSTS:308251

ZK1098.4 (e-PCR)
- UniSTS:310407

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables 3'-5' exonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3'-5' exonuclease activity	IEA Inferred from Electronic Annotation more info
enables 3'-5'-exoribonuclease activity involved in mature miRNA 3'-end processing	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables exonuclease activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in associative learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleobase-containing compound metabolic process	IEA Inferred from Electronic Annotation more info
involved_in olfactory learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in post-transcriptional gene silencing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pre-miRNA 3'-end processing	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in regulatory ncRNA-mediated gene silencing	IEA Inferred from Electronic Annotation more info
involved_in regulatory ncRNA-mediated post-transcriptional gene silencing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in mutator focus	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Exonuclease mut-7

NP_499105.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

9539031..9542380 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066704.10 → NP_499105.1 Exonuclease mut-7 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_499105.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P34607

Conserved Domains (2) summary

cd06146
Location:404 → 602

mut-7_like_exo; DEDDy 3'-5' exonuclease domain of Caenorhabditis elegans mut-7 and similar proteins

cl19501
Location:665 → 775

Mut7-C; Mut7-C RNAse domain