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    hum-6 Unconventional myosin heavy chain 6 [ Caenorhabditis elegans ]

    Gene ID: 180539, updated on 9-Dec-2024

    Summary

    Official Symbol
    hum-6
    Official Full Name
    Unconventional myosin heavy chain 6
    Primary source
    WormBase:WBGene00002039
    Locus tag
    CELE_T10H10.1
    See related
    AllianceGenome:WB:WBGene00002039
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in several processes, including actin filament organization; actin filament-based movement; and sensory perception of sound. Predicted to be located in cytoskeleton. Predicted to be part of myosin VI complex. Predicted to be active in several cellular components, including actin cytoskeleton; cytoplasm; and microvillus. Human ortholog(s) of this gene implicated in Leber congenital amaurosis; Usher syndrome (multiple); auditory system disease (multiple); and congenital nystagmus. Orthologous to several human genes including MYO7A (myosin VIIA). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See hum-6 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    27
    Sequence:
    Chromosome: X; NC_003284.9 (2303082..2314914)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Sulfhydryl oxidase Neighboring gene ncRNA Neighboring gene CBS domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cytoskeletal motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in actin filament-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sensory organ development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sensory perception of sound IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in microvillus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of myosin VI complex TAS
    Traceable Author Statement
    more info
    PubMed 
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    Unconventional myosin heavy chain 6
    NP_508420.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      2303082..2314914
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076019.6NP_508420.1  Unconventional myosin heavy chain 6 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508420.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P91443
      Conserved Domains (9) summary
      smart00015
      Location:757779
      IQ; Calmodulin-binding motif
      smart00139
      Location:16241772
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00242
      Location:57731
      MYSc; Myosin. Large ATPases
      smart00295
      Location:17791993
      B41; Band 4.1 homologues
      cd13198
      Location:13821480
      FERM_C1_MyoVII; FERM domain C-lobe, repeat 1, of Myosin VII (MyoVII/Myo7)
      cd13199
      Location:19892087
      FERM_C2_MyoVII; FERM domain C-lobe, repeat 2, of Myosin VII (MyoVII, Myo7)
      cd14473
      Location:18901985
      FERM_B-lobe; FERM domain B-lobe
      cd01381
      Location:76720
      MYSc_Myo7; class VII myosin, motor domain
      cl17036
      Location:14811544
      SH3; Src Homology 3 domain superfamily