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    dpy-9 Nematode cuticle collagen N-terminal domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 176846, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dpy-9
    Official Full Name
    Nematode cuticle collagen N-terminal domain-containing protein
    Primary source
    WormBase:WBGene00001071
    Locus tag
    CELE_T21D12.2
    See related
    AllianceGenome:WB:WBGene00001071
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be a structural constituent of cuticle. Involved in regulation of gene expression. Predicted to be located in membrane. Predicted to be part of collagen trimer. Used to study skin disease. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dpy-9 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    4
    Sequence:
    Chromosome: IV; NC_003282.8 (257403..259204, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene C2H2-type domain-containing protein Neighboring gene Exonuclease domain-containing protein Neighboring gene WW domain-containing protein Neighboring gene Paralyzed arrest at two-fold protein 6

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A gene involved in action of tumor promoters is identified and mapped in Caenorhabditis elegans. Tabuse Y, et al. Carcinogenesis, 1983. PMID 6861282
    2. Developmental function and state transitions of a gene expression oscillator in Caenorhabditis elegans. Meeuse MW, et al. Mol Syst Biol, 2020 Jul. PMID 32687264, Free PMC Article
    3. Loss of dpy-2 and dpy-9 has stage-specific effects on DBL-1 pathway signaling. Lakdawala MF, et al. MicroPubl Biol, 2019 Dec 9. PMID 32550453, Free PMC Article
    4. Activation of a G protein-coupled receptor by its endogenous ligand triggers the innate immune response of Caenorhabditis elegans. Zugasti O, et al. Nat Immunol, 2014 Sep. PMID 25086774, Free PMC Article
    5. A pre- and co-knockdown of RNAseT enzyme, Eri-1, enhances the efficiency of RNAi induced gene silencing in Caenorhabditis elegans. Jadiya P, et al. PLoS One, 2014. PMID 24475317, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables structural constituent of cuticle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of collagen trimer IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nematode cuticle collagen N-terminal domain-containing protein
    NP_001294332.1
    • Confirmed by transcript evidence
    NP_499889.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      257403..259204 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067488.9 → NP_499889.2  Nematode cuticle collagen N-terminal domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499889.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O16787
      Conserved Domains (2) summary
      pfam01391
      Location:220 → 269
      Collagen; Collagen triple helix repeat (20 copies)
      pfam01484
      Location:13 → 61
      Col_cuticle_N; Nematode cuticle collagen N-terminal domain

    2. NM_001307403.3 → NP_001294332.1  Nematode cuticle collagen N-terminal domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294332.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PBE1
      Conserved Domains (2) summary
      pfam01391
      Location:93 → 133
      Collagen; Collagen triple helix repeat (20 copies)
      pfam01484
      Location:13 → 61
      Col_cuticle_N; Nematode cuticle collagen N-terminal domain
    Nucleotide Protein
    Heading Accession and Version

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