D1054.1 PNPLA domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: D1054.1
Official Full Name: PNPLA domain-containing protein
Primary source: WormBase:WBGene00008370
Locus tag: CELE_D1054.1
See related: AllianceGenome:WB:WBGene00008370
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable triacylglycerol lipase activity. Predicted to be involved in lipid homeostasis and triglyceride catabolic process. Predicted to be active in cytoplasm; lipid droplet; and membrane. Is expressed in reproductive system. Orthologous to human PNPLA4 (patatin like phospholipase domain containing 4). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See D1054.1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 8

Sequence:: Chromosome: V; NC_003283.11 (10768463..10770217, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1054.1 (e-PCR)
- UniSTS:317700

D1054.2 (e-PCR)
- UniSTS:320902

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables triacylglycerol lipase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in retinol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in triglyceride catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in lipid droplet	IBA Inferred from Biological aspect of Ancestor more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: PNPLA domain-containing protein

NP_505749.3

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

10768463..10770217 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_073348.7 → NP_505749.3 PNPLA domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_505749.3

Status: REVIEWED

UniProtKB/TrEMBL

Q18948

Conserved Domains (1) summary

cd07222
Location:21 → 266

Pat_PNPLA4; Patatin-like phospholipase domain containing protein 4