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    gpx-7 Glutathione peroxidase [ Caenorhabditis elegans ]

    Gene ID: 187542, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gpx-7
    Official Full Name
    Glutathione peroxidase
    Primary source
    WormBase:WBGene00019846
    Locus tag
    CELE_R03G5.5
    See related
    AllianceGenome:WB:WBGene00019846
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable peroxidase activity. Predicted to be involved in cellular oxidant detoxification and response to oxidative stress. Located in cytosol. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma; colorectal cancer; and spondylometaphyseal dysplasia Sedaghatian type. Orthologous to human GPX4 (glutathione peroxidase 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gpx-7 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    3
    Sequence:
    Chromosome: X; NC_003284.9 (7798949..7799780, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene tRNA-Gly Neighboring gene Disintegrin and metalloproteinase domain-containing protein 17 homolog Neighboring gene pseudo Neighboring gene 2TM domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ginkgo seed extract promotes longevity and stress resistance of Caenorhabditis elegans. Shen N, et al. Food Funct, 2021 Dec 13. PMID 34812833
    2. Deletion of the four phospholipid hydroperoxide glutathione peroxidase genes accelerates aging in Caenorhabditis elegans. Sakamoto T, et al. Genes Cells, 2014 Oct. PMID 25200408
    3. Mitochondrial thioredoxin system is required for enhanced stress resistance and extended longevity in long-lived mitochondrial mutants. Harris-Gauthier N, et al. Redox Biol, 2022 Jul. PMID 35598379, Free PMC Article
    4. Specific collagens maintain the cuticle permeability barrier in Caenorhabditis elegans. Sandhu A, et al. Genetics, 2021 Mar 31. PMID 33789349, Free PMC Article
    5. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables peroxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Glutathione peroxidase
    NP_001123171.1
    • Partially confirmed by transcript evidence
    NP_001359951.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      7798949..7799780 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001373375.2 → NP_001359951.1  Glutathione peroxidase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8WFK7
      Conserved Domains (1) summary
      cl00388
      Location:32 → 105
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    2. NM_001129699.5 → NP_001123171.1  Glutathione peroxidase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001123171.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8WFK6
      Conserved Domains (1) summary
      cd00340
      Location:32 → 188
      GSH_Peroxidase; Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per ...
    Nucleotide Protein
    Heading Accession and Version

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