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    nas-33 Zinc metalloproteinase nas-33 [ Caenorhabditis elegans ]

    Gene ID: 186987, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nas-33
    Official Full Name
    Zinc metalloproteinase nas-33
    Primary source
    WormBase:WBGene00003551
    Locus tag
    CELE_K04E7.3
    See related
    AllianceGenome:WB:WBGene00003551
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in molting cycle and proteolysis. Predicted to be located in extracellular region. Is expressed in hyp12; intestine; and tail hypodermis. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nas-33 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    19
    Sequence:
    Chromosome: X; NC_003284.9 (6451698..6455257, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Fumarylacetoacetase Neighboring gene Ground-like domain-containing protein Neighboring gene Serpentine Receptor, class BC (Class B-like) Neighboring gene ncRNA Neighboring gene Peptide transporter family 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Metalloproteases with EGF, CUB, and thrombospondin-1 domains function in molting of Caenorhabditis elegans. Suzuki M, et al. Biol Chem, 2004 Jun. PMID 15255192
    2. The astacin protein family in Caenorhabditis elegans. Möhrlen F, et al. Eur J Biochem, 2003 Dec. PMID 14653817
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in molting cycle, collagen and cuticulin-based cuticle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Zinc metalloproteinase nas-33
    NP_509086.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      6451698..6455257 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076685.4 → NP_509086.2  Zinc metalloproteinase nas-33 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509086.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P55114, Q7Z0M0
      Conserved Domains (4) summary
      smart00209
      Location:553 → 595
      TSP1; Thrombospondin type 1 repeats
      cd04280
      Location:203 → 381
      ZnMc_astacin_like; Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of zinc-dependent proteolytic enzymes with a HExxH zinc-binding site/active site. Members of this family may have an amino terminal propeptide, which is cleaved to ...
      pfam01400
      Location:200 → 386
      Astacin; Astacin (Peptidase family M12A)
      cl00049
      Location:442 → 527
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P55114.2

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