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    inx-6 Innexin-6 [ Caenorhabditis elegans ]

    Gene ID: 178231, updated on 9-Dec-2024

    Summary

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    Official Symbol
    inx-6
    Official Full Name
    Innexin-6
    Primary source
    WormBase:WBGene00002128
    Locus tag
    CELE_C36H8.2
    See related
    AllianceGenome:WB:WBGene00002128
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable gap junction hemi-channel activity. Predicted to be involved in monoatomic ion transmembrane transport. Predicted to be active in gap junction and plasma membrane. Is expressed in head neurons; pharynx; and rectal valve cell. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See inx-6 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    8
    Sequence:
    Chromosome: IV; NC_003282.8 (12746584..12749721)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene MAM domain-containing protein Neighboring gene ncRNA Neighboring gene Major sperm protein Neighboring gene KPSFVRF-amide 2 Neighboring gene SHSP domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cryo-EM structures of undocked innexin-6 hemichannels in phospholipids. Burendei B, et al. Sci Adv, 2020 Feb. PMID 32095518, Free PMC Article
    2. Atomic structure of the innexin-6 gap junction channel determined by cryo-EM. Oshima A, et al. Nat Commun, 2016 Dec 1. PMID 27905396, Free PMC Article
    3. Oligomeric structure and functional characterization of Caenorhabditis elegans Innexin-6 gap junction protein. Oshima A, et al. J Biol Chem, 2013 Apr 12. PMID 23460640, Free PMC Article
    4. Hexadecameric structure of an invertebrate gap junction channel. Oshima A, et al. J Mol Biol, 2016 Mar 27. PMID 26883891
    5. Regulation of intermuscular electrical coupling by the Caenorhabditis elegans innexin inx-6. Li S, et al. Mol Biol Cell, 2003 Jul. PMID 12857852, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cryo-EM structures of undocked innexin-6 hemichannels in phospholipids.
      Title: Cryo-EM structures of undocked innexin-6 hemichannels in phospholipids.
    2. the INX-6 cytoplasmic domains are cooperatively associated with the N-terminal funnel conformation, and an essential linkage of the N-terminal with channel activity is presumably preserved across gap junction families.
      Title: Atomic structure of the innexin-6 gap junction channel determined by cryo-EM.
    3. The three-dimensional reconstruction determined by cryo-electron crystallography reveals that a single INX-6 gap junction channel comprises 16 subunits, a hexadecamer, in contrast to chordate connexin channels, which comprise 12 subunits.
      Title: Hexadecameric structure of an invertebrate gap junction channel.
    4. INX-6 channels have a larger overall structure and greater permeability than connexin channels.
      Title: Oligomeric structure and functional characterization of Caenorhabditis elegans Innexin-6 gap junction protein.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables gap junction channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables gap junction channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables gap junction hemi-channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in gap junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in gap junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in gap junction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Innexin-6
    NP_502435.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      12746584..12749721
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_070034.5 → NP_502435.1  Innexin-6 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502435.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q17395, Q9U3N4
      Conserved Domains (1) summary
      pfam00876
      Location:25 → 364
      Innexin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9U3N4.1

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