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    ceh-60 Homeobox protein ceh-60 [ Caenorhabditis elegans ]

    Gene ID: 184803, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ceh-60
    Official Full Name
    Homeobox protein ceh-60
    Primary source
    WormBase:WBGene00017690
    Locus tag
    CELE_F22A3.5
    See related
    AllianceGenome:WB:WBGene00017690
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in dopaminergic neuron differentiation and regulation of transcription by RNA polymerase II. Acts upstream of or within lipid homeostasis. Located in chromatin. Is expressed in amphid neurons; intestine; and sensory neurons. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ceh-60 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    10
    Sequence:
    Chromosome: X; NC_003284.9 (6522596..6530146, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Transcription factor ets-4 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene lysozyme Neighboring gene Secreted protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Unraveling effects of anti-aging drugs on C. elegans using liposomes. Zhang A, et al. Geroscience, 2023 Jun. PMID 37140725, Free PMC Article
    2. CEH-60/PBX and UNC-62/MEIS Coordinate a Metabolic Switch that Supports Reproduction in C. elegans. Dowen RH. Dev Cell, 2019 Apr 22. PMID 30956009
    3. CEH-60/PBX regulates vitellogenesis and cuticle permeability through intestinal interaction with UNC-62/MEIS in Caenorhabditis elegans. Van de Walle P, et al. PLoS Biol, 2019 Nov. PMID 31675356, Free PMC Article
    4. DamID identifies targets of CEH-60/PBX that are associated with neuron development and muscle structure in Caenorhabditis elegans. Van de Walle P, et al. PLoS One, 2020. PMID 33306687, Free PMC Article
    5. A combinatorial regulatory signature controls terminal differentiation of the dopaminergic nervous system in C. elegans. Doitsidou M, et al. Genes Dev, 2013 Jun 15. PMID 23788625, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DamID identifies targets of CEH-60/PBX that are associated with neuron development and muscle structure in Caenorhabditis elegans.
      Title: DamID identifies targets of CEH-60/PBX that are associated with neuron development and muscle structure in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in dopaminergic neuron differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within lipid homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Homeobox protein ceh-60
    NP_509101.4
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      6522596..6530146 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076700.6 → NP_509101.4  Homeobox protein ceh-60 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509101.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q45EK2
      Conserved Domains (2) summary
      COG5576
      Location:138 → 280
      COG5576; Homeodomain-containing transcription factor [Transcription]
      pfam05920
      Location:198 → 237
      Homeobox_KN; Homeobox KN domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q45EK2.3

    Gene LinkOut

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