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    fars-1 phenylalanine--tRNA ligase [ Caenorhabditis elegans ]

    Gene ID: 172311, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fars-1
    Official Full Name
    phenylalanine--tRNA ligase
    Primary source
    WormBase:WBGene00001497
    Locus tag
    CELE_T08B2.9
    See related
    AllianceGenome:WB:WBGene00001497
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable phenylalanine-tRNA ligase activity. Involved in translation. Predicted to be part of phenylalanine-tRNA ligase complex. Predicted to be active in cytoplasm. Orthologous to human FARSA (phenylalanyl-tRNA synthetase subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See fars-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    9
    Sequence:
    Chromosome: I; NC_003279.8 (6211983..6214586, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Enoyl-CoA hydratase Neighboring gene Large ribosomal subunit protein uL23m Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA Neighboring gene Activin_recp domain-containing protein Neighboring gene RNA-binding protein 5 Neighboring gene Small ribosomal subunit protein eS17

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. GCN-2 dependent inhibition of protein synthesis activates osmosensitive gene transcription via WNK and Ste20 kinase signaling. Lee EC, et al. Am J Physiol Cell Physiol, 2012 Dec 15. PMID 23076791, Free PMC Article
    2. Alignment of the genetic and physical maps in the dpy-5 bli-4 (I) region of C. elegans by the serial cosmid rescue of lethal mutations. McDowall JS, et al. Mol Gen Genet, 1997 Jun. PMID 9230901
    3. Global Proteomic Response of Caenorhabditis elegans Against PemK(Sa) Toxin. Mir DA, et al. Front Cell Infect Microbiol, 2019. PMID 31214513, Free PMC Article
    4. Genetic analysis of sterile mutants in the dpy-5 unc-13 (I) genomic region of Caenorhabditis elegans. McDowall JS, et al. Mol Gen Genet, 1997 Jun. PMID 9230900
    5. Allelic ratios and the mutational landscape reveal biologically significant heterozygous SNVs. Chu JS, et al. Genetics, 2012 Apr. PMID 22267497, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phenylalanine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phenylalanine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in phenylalanyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phenylalanyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of phenylalanine-tRNA ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    phenylalanine--tRNA ligase
    NP_001379817.1
    • Confirmed by transcript evidence
    NP_491792.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      6211983..6214586 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059391.6 → NP_491792.1  phenylalanine--tRNA ligase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491792.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9GYS8
      Conserved Domains (2) summary
      PTZ00326
      Location:65 → 539
      PTZ00326; phenylalanyl-tRNA synthetase alpha chain; Provisional
      cl02776
      Location:7 → 55
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

    2. NM_001392410.1 → NP_001379817.1  phenylalanine--tRNA ligase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86B36
      Conserved Domains (1) summary
      PTZ00326
      Location:9 → 483
      PTZ00326; phenylalanyl-tRNA synthetase alpha chain; Provisional
    Nucleotide Protein
    Heading Accession and Version

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