jmjd-5 Glucosamine 6-phosphate N-acetyltransferase;N-acetyltransferase domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: jmjd-5
Official Full Name: Glucosamine 6-phosphate N-acetyltransferase;N-acetyltransferase domain-containing protein
Primary source: WormBase:WBGene00007387
Locus tag: CELE_C06H2.3
See related: AllianceGenome:WB:WBGene00007387
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable chromatin binding activity; histone H3K36 demethylase activity; and peptidyl-arginine 3-dioxygenase activity. Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to be active in nucleus. Orthologous to human KDM8 (lysine demethylase 8). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See jmjd-5 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 9

Sequence:: Chromosome: V; NC_003283.11 (11127497..11130095)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Coordinated maintenance of H3K36/K27 methylation by histone demethylases preserves germ cell identity and immortality.
Title: Coordinated maintenance of H3K36/K27 methylation by histone demethylases preserves germ cell identity and immortality.
Analyses of jmjd-5 genetic interactions with genes required for resolving recombination intermediates (rtel-1) or promoting the resolution of RAD-51 double stranded DNA filaments (rfs-1 and helq-1) suggest that jmjd-5 prevents the formation of stalled postsynaptic recombination intermediates and favors RAD-51 removal.
Title: JMJD-5/KDM8 regulates H3K36me2 and is required for late steps of homologous recombination and genome integrity.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C06H2.2 (e-PCR)
- UniSTS:307217

C06H2.3 (e-PCR)
- UniSTS:306503

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables acyltransferase activity, transferring groups other than amino-acyl groups	IEA Inferred from Electronic Annotation more info
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables glucosamine 6-phosphate N-acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K36 demethylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptidyl-arginine 3-dioxygenase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in UDP-N-acetylglucosamine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Glucosamine 6-phosphate N-acetyltransferase;N-acetyltransferase domain-containing protein

NP_001346729.1

Confirmed by transcript evidence

NP_505831.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

11127497..11130095

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_073430.4 → NP_505831.1 Glucosamine 6-phosphate N-acetyltransferase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_505831.1

Status: REVIEWED

UniProtKB/TrEMBL

Q17765

Conserved Domains (2) summary

pfam13621
Location:360 → 578

Cupin_8; Cupin-like domain

cl17182
Location:26 → 137

NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate
NM_001359791.3 → NP_001346729.1 N-acetyltransferase domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A2I2LDX7

Conserved Domains (1) summary

cl17182
Location:26 → 137

NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate