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    rgs-7 C2 domain-containing protein;RGS domain-containing protein;Regulator of G-protein signaling rgs-7 [ Caenorhabditis elegans ]

    Gene ID: 180645, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rgs-7
    Official Full Name
    C2 domain-containing protein;RGS domain-containing protein;Regulator of G-protein signaling rgs-7
    Primary source
    WormBase:WBGene00004350
    Locus tag
    CELE_F56B6.2
    See related
    AllianceGenome:WB:WBGene00004350
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables GTPase activator activity. Predicted to be involved in negative regulation of signal transduction. Located in cell cortex. Is expressed in head neurons. Orthologous to several human genes including RGS1 (regulator of G protein signaling 1); RGS13 (regulator of G protein signaling 13); and RGS18 (regulator of G protein signaling 18). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rgs-7 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    18
    Sequence:
    Chromosome: X; NC_003284.9 (3542542..3557783)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene CC domain-containing protein Neighboring gene Glycogenin-1 Neighboring gene Vitellogenin-4 Neighboring gene ncRNA Neighboring gene Vitellogenin-3 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A conserved protein interaction interface on the type 5 G protein beta subunit controls proteolytic stability and activity of R7 family regulator of G protein signaling proteins. Porter MY, et al. J Biol Chem, 2010 Dec 24. PMID 20959458, Free PMC Article
    2. Characterization of a novel C. elegans RGS protein with a C2 domain: evidence for direct association between C2 domain and Galphaq subunit. Sato M, et al. Life Sci, 2003 Jul 4. PMID 12798417
    3. RGS-7 completes a receptor-independent heterotrimeric G protein cycle to asymmetrically regulate mitotic spindle positioning in C. elegans. Hess HA, et al. Cell, 2004 Oct 15. PMID 15479638
    4. A point mutation to Galphai selectively blocks GoLoco motif binding: direct evidence for Galpha.GoLoco complexes in mitotic spindle dynamics. Willard FS, et al. J Biol Chem, 2008 Dec 26. PMID 18984596, Free PMC Article
    5. Heterotrimeric G proteins: new tricks for an old dog. Hampoelz B, et al. Cell, 2004 Nov 12. PMID 15537535

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. conserved protein interaction interface on the type 5 G protein beta subunit controls proteolytic stability and activity of R7 family regulator of G protein signaling proteins.
      Title: A conserved protein interaction interface on the type 5 G protein beta subunit controls proteolytic stability and activity of R7 family regulator of G protein signaling proteins.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    C2 domain-containing protein;RGS domain-containing protein;Regulator of G-protein signaling rgs-7
    NP_001024714.1
    • Confirmed by transcript evidence
    NP_001024715.1
    • Confirmed by transcript evidence
    NP_001123153.1
    • Confirmed by transcript evidence
    NP_001123154.1
    • Confirmed by transcript evidence
    NP_001360776.1
    • Confirmed by transcript evidence
    NP_001360777.1
    • Confirmed by transcript evidence
    NP_001360778.1
    • Confirmed by transcript evidence
    NP_001361946.1
    • Confirmed by transcript evidence
    NP_508610.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      3542542..3557783
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076209.7 → NP_508610.3  Regulator of G-protein signaling rgs-7 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508610.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8WQC0, Q95Q48, Q95Q49
      Conserved Domains (2) summary
      smart00239
      Location:308 → 425
      C2; Protein kinase C conserved region 2 (CalB)
      pfam00615
      Location:682 → 787
      RGS; Regulator of G protein signaling domain

    2. NM_001373260.4 → NP_001360776.1  C2 domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0IKM4
      Conserved Domains (2) summary
      smart00239
      Location:310 → 427
      C2; Protein kinase C conserved region 2 (CalB)
      pfam00615
      Location:687 → 792
      RGS; Regulator of G protein signaling domain

    3. NM_001373261.4 → NP_001360777.1  C2 domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0IJG9
      Conserved Domains (2) summary
      smart00239
      Location:310 → 427
      C2; Protein kinase C conserved region 2 (CalB)
      pfam00615
      Location:684 → 789
      RGS; Regulator of G protein signaling domain

    4. NM_001373262.3 → NP_001360778.1  C2 domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0ILX5
      Conserved Domains (2) summary
      smart00239
      Location:308 → 425
      C2; Protein kinase C conserved region 2 (CalB)
      pfam00615
      Location:685 → 790
      RGS; Regulator of G protein signaling domain

    5. NM_001029543.5 → NP_001024714.1  Regulator of G-protein signaling rgs-7 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024714.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8WQC0
      Conserved Domains (2) summary
      smart00239
      Location:271 → 388
      C2; Protein kinase C conserved region 2 (CalB)
      pfam00615
      Location:645 → 750
      RGS; Regulator of G protein signaling domain

    6. NM_001029544.6 → NP_001024715.1  Regulator of G-protein signaling rgs-7 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024715.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8WQC0
      Conserved Domains (1) summary
      pfam00615
      Location:287 → 392
      RGS; Regulator of G protein signaling domain

    7. NM_001374994.1 → NP_001361946.1  RGS domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q1W0R0
      Conserved Domains (1) summary
      pfam00615
      Location:187 → 292
      RGS; Regulator of G protein signaling domain

    8. NM_001129681.4 → NP_001123153.1  RGS domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001123153.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KYQ7
      Conserved Domains (1) summary
      pfam00615
      Location:103 → 208
      RGS; Regulator of G protein signaling domain

    9. NM_001129682.5 → NP_001123154.1  RGS domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001123154.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KYQ8
      Conserved Domains (1) summary
      pfam00615
      Location:78 → 183
      RGS; Regulator of G protein signaling domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8WQC0.2

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