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    vab-8 Kinesin-like protein vab-8 [ Caenorhabditis elegans ]

    Gene ID: 179675, updated on 9-Dec-2024

    Summary

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    Official Symbol
    vab-8
    Official Full Name
    Kinesin-like protein vab-8
    Primary source
    WormBase:WBGene00006874
    Locus tag
    CELE_K12F2.2
    See related
    AllianceGenome:WB:WBGene00006874
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATP binding activity; microtubule binding activity; and microtubule motor activity. Involved in several processes, including egg-laying behavior; generation of neurons; and negative regulation of motor neuron migration. Located in striated muscle thin filament. Is expressed in body wall musculature and neurons. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations. Orthologous to human KIF26A (kinesin family member 26A) and KIF26B (kinesin family member 26B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See vab-8 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    16
    Sequence:
    Chromosome: V; NC_003283.11 (12213327..12225934)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Myosin-3 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Neurexin and frizzled intercept axonal transport at microtubule minus ends to control synapse formation. Balseiro-Gómez S, et al. Dev Cell, 2022 Aug 8. PMID 35809561, Free PMC Article
    2. The conserved kinase UNC-51 acts with VAB-8 and UNC-14 to regulate axon outgrowth in C. elegans. Lai T, et al. Development, 2004 Dec. PMID 15539493
    3. Receptors on neurons help shape worm development. Robinson R. PLoS Biol, 2013. PMID 23319890, Free PMC Article
    4. Parallel Rap1>RalGEF>Ral and Ras signals sculpt the C. elegans nervous system. Mardick JI, et al. Dev Biol, 2021 Sep. PMID 33991533, Free PMC Article
    5. vab-8 is a key regulator of posteriorly directed migrations in C. elegans and encodes a novel protein with kinesin motor similarity. Wolf FW, et al. Neuron, 1998 Apr. PMID 9581759

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Here, using the C. elegans PLM neurons as a model, we show that UNC-44/ankyrin acts upstream of UNC-33/CRMP in regulation of a potential kinesin VAB-8 to control gap junction dynamics
      Title: Regulation of Gap Junction Dynamics by UNC-44/ankyrin and UNC-33/CRMP through VAB-8 in C. elegans Neurons.
    2. VAB-8 and UNC-14 are substrates that mediate the function of UNC-51 in axon outgrowth
      Title: The conserved kinase UNC-51 acts with VAB-8 and UNC-14 to regulate axon outgrowth in C. elegans.
    3. VAB-8L directs cell and growth-cone migrations by promoting localization of guidance receptors to the cell surface.
      Title: C. elegans VAB-8 and UNC-73 regulate the SAX-3 receptor to direct cell and growth-cone migrations.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in egg-laying behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mesodermal cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of motor neuron migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of motor neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vulval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in striated muscle thin filament IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Kinesin-like protein vab-8
    NP_001122977.1
    • Confirmed by transcript evidence
    NP_506063.2
    • Confirmed by transcript evidence
    NP_506064.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      12213327..12225934
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073662.7 → NP_506063.2  Kinesin-like protein vab-8 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506063.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q21441, Q9TVW0, Q9U541
      Conserved Domains (1) summary
      cl22853
      Location:54 → 300
      Motor_domain; Myosin and Kinesin motor domain

    2. NM_001129505.5 → NP_001122977.1  Kinesin-like protein vab-8 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122977.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DZ45

    3. NM_073663.6 → NP_506064.1  Kinesin-like protein vab-8 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506064.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q21441
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q21441.3

    Gene LinkOut

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