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    W04G3.5 Ribose-phosphate pyrophosphokinase N-terminal domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 181299, updated on 9-Dec-2024

    Summary

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    Official Symbol
    W04G3.5
    Official Full Name
    Ribose-phosphate pyrophosphokinase N-terminal domain-containing protein
    Primary source
    WormBase:WBGene00012258
    Locus tag
    CELE_W04G3.5
    See related
    AllianceGenome:WB:WBGene00012258
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable enzyme regulator activity. Predicted to be involved in 5-phosphoribose 1-diphosphate biosynthetic process and purine nucleotide biosynthetic process. Predicted to be active in cytoplasm. Is expressed in intestine and pharynx. Orthologous to human PRPSAP1 (phosphoribosyl pyrophosphate synthetase associated protein 1) and PRPSAP2 (phosphoribosyl pyrophosphate synthetase associated protein 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See W04G3.5 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    8
    Sequence:
    Chromosome: X; NC_003284.9 (11073658..11075961)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene LiPocalin-Related protein Neighboring gene ADP-ribosylation factor-binding protein GGA1 Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
    2. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
    3. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables enzyme regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribose phosphate diphosphokinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 5-phosphoribose 1-diphosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in purine nucleotide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Ribose-phosphate pyrophosphokinase N-terminal domain-containing protein
    NP_001257131.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      11073658..11075961
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001270202.5 → NP_001257131.1  Ribose-phosphate pyrophosphokinase N-terminal domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001257131.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q23166
      Conserved Domains (2) summary
      pfam14572
      Location:167 → 347
      Pribosyl_synth; Phosphoribosyl synthetase-associated domain
      pfam13793
      Location:11 → 126
      Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
    Nucleotide Protein
    Heading Accession and Version

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