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    maoc-1 MaoC-like domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 174181, updated on 9-Dec-2024

    Summary

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    Official Symbol
    maoc-1
    Official Full Name
    MaoC-like domain-containing protein
    Primary source
    WormBase:WBGene00017123
    Locus tag
    CELE_E04F6.3
    See related
    AllianceGenome:WB:WBGene00017123
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables identical protein binding activity. Involved in defense response to Gram-negative bacterium and innate immune response. Predicted to be located in peroxisomal membrane. Predicted to be active in peroxisome. Is expressed in intestine. Used to study obesity. Human ortholog(s) of this gene implicated in D-bifunctional protein deficiency; Perrault syndrome; and Stiff-Person syndrome. Orthologous to human HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See maoc-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    4
    Sequence:
    Chromosome: II; NC_003280.10 (7196276..7197495)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene PLD phosphodiesterase domain-containing protein Neighboring gene Very long-chain specific acyl-CoA dehydrogenase, mitochondrial Neighboring gene ncRNA Neighboring gene Secreted protein Neighboring gene ncRNA Neighboring gene Parkin coregulated gene protein homolog

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Comparative metabolomics reveals biogenesis of ascarosides, a modular library of small-molecule signals in C. elegans. von Reuss SH, et al. J Am Chem Soc, 2012 Jan 25. PMID 22239548, Free PMC Article
    2. Genetic and dietary regulation of lipid droplet expansion in Caenorhabditis elegans. Zhang SO, et al. Proc Natl Acad Sci U S A, 2010 Mar 9. PMID 20176933, Free PMC Article
    3. Peroxisome protein transportation affects metabolism of branched-chain fatty acids that critically impact growth and development of C. elegans. Wang R, et al. PLoS One, 2013. PMID 24086720, Free PMC Article
    4. A Genetic Screen for Mutants with Supersized Lipid Droplets in Caenorhabditis elegans. Li S, et al. G3 (Bethesda), 2016 Aug 9. PMID 27261001, Free PMC Article
    5. Polyunsaturated fatty acids promote the rapid fusion of lipid droplets in Caenorhabditis elegans. Wang Y, et al. J Biol Chem, 2022 Aug. PMID 35752365, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 17-beta-hydroxysteroid dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3-hydroxyacyl-CoA dehydratase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables 3-hydroxyacyl-CoA dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables enoyl-CoA hydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fatty acid beta-oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid beta-oxidation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in peroxisomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    MaoC-like domain-containing protein
    NP_495494.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      7196276..7197495
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063093.5 → NP_495494.1  MaoC-like domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495494.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q19058
      Conserved Domains (3) summary
      PLN02864
      Location:2 → 282
      PLN02864; enoyl-CoA hydratase
      cd03448
      Location:160 → 282
      HDE_HSD; HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit.
      cl00509
      Location:45 → 130
      hot_dog; The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated ...
    Nucleotide Protein
    Heading Accession and Version

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