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    nmr-2 Ionotropic glutamate receptor C-terminal domain-containing protein;PBPe domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 180002, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nmr-2
    Official Full Name
    Ionotropic glutamate receptor C-terminal domain-containing protein;PBPe domain-containing protein
    Primary source
    WormBase:WBGene00003775
    Locus tag
    CELE_T01C3.10
    See related
    AllianceGenome:WB:WBGene00003775
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable NMDA glutamate receptor activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in glutamatergic synaptic transmission and modulation of chemical synaptic transmission. Predicted to be located in postsynaptic membrane. Predicted to be active in postsynaptic density membrane. Is expressed in AVG; RIM; and command interneuron. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcohol use disorder; autosomal dominant intellectual developmental disorder 6; developmental and epileptic encephalopathy (multiple); and neurodegenerative disease (multiple). Orthologous to several human genes including GRIN2C (glutamate ionotropic receptor NMDA type subunit 2C). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nmr-2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    20
    Sequence:
    Chromosome: V; NC_003283.11 (15006341..15011660, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene rRNA 2'-O-methyltransferase fibrillarin Neighboring gene MUTator Neighboring gene Protein hrde-2 Neighboring gene Oxysterol binding protein;Oxysterol-binding protein Neighboring gene ncRNA Neighboring gene tRNA-Val Neighboring gene SPX domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Caenorhabditis elegans as a model for studies on quinolinic acid-induced NMDAR-dependent glutamatergic disorders. Limana da Silveira T, et al. Brain Res Bull, 2021 Oct. PMID 34271120, Free PMC Article
    2. NRAP-1 Is a Presynaptically Released NMDA Receptor Auxiliary Protein that Modifies Synaptic Strength. Lei N, et al. Neuron, 2017 Dec 20. PMID 29224722, Free PMC Article
    3. d-Serine and d-Alanine Regulate Adaptive Foraging Behavior in Caenorhabditis elegans via the NMDA Receptor. Saitoh Y, et al. J Neurosci, 2020 Sep 23. PMID 32855271, Free PMC Article
    4. Glial loss of the metallo β-lactamase domain containing protein, SWIP-10, induces age- and glutamate-signaling dependent, dopamine neuron degeneration. Gibson CL, et al. PLoS Genet, 2018 Mar. PMID 29590100, Free PMC Article
    5. Memory in Caenorhabditis elegans is mediated by NMDA-type ionotropic glutamate receptors. Kano T, et al. Curr Biol, 2008 Jul 8. PMID 18583134, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables NMDA glutamate receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ionotropic glutamate receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in modulation of chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in synaptic transmission, glutamatergic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynaptic density membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ionotropic glutamate receptor C-terminal domain-containing protein;PBPe domain-containing protein
    NP_001256640.1
    • Confirmed by transcript evidence
    NP_001256641.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      15006341..15011660 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001269711.3 → NP_001256640.1  PBPe domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256640.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EEH3
      Conserved Domains (3) summary
      TIGR03975
      Location:54 → 108
      rSAM_ocin_1; ribosomal peptide maturation radical SAM protein 1
      cl10011
      Location:102 → 443
      Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
      cl21456
      Location:460 → 860
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily

    2. NM_001269712.1 → NP_001256641.1  Ionotropic glutamate receptor C-terminal domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256641.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E0AHC1
      Conserved Domains (1) summary
      cl21456
      Location:1 → 299
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
    Nucleotide Protein
    Heading Accession and Version

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