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    clh-4 Chloride channel protein [ Caenorhabditis elegans ]

    Gene ID: 180687, updated on 9-Dec-2024

    Summary

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    Official Symbol
    clh-4
    Official Full Name
    Chloride channel protein
    Primary source
    WormBase:WBGene00000531
    Locus tag
    CELE_T06F4.2
    See related
    AllianceGenome:WB:WBGene00000531
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable voltage-gated chloride channel activity. Predicted to be involved in chloride transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in excretory cell. Human ortholog(s) of this gene implicated in Becker disease; Thomsen disease; idiopathic generalized epilepsy 11; myotonia congenita; and primary hyperaldosteronism. Orthologous to human CLCN1 (chloride voltage-gated channel 1) and CLCN2 (chloride voltage-gated channel 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See clh-4 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    20
    Sequence:
    Chromosome: X; NC_003284.9 (4094867..4100573, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ovule protein Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pediococcus acidilactici Promotes the Longevity of C. elegans by Regulating the Insulin/IGF-1 and JNK/MAPK Signaling, Fat Accumulation and Chloride Ion. Hu R, et al. Front Nutr, 2022. PMID 35433778, Free PMC Article
    2. Characterization of a novel voltage-dependent outwardly rectifying anion current in Caenorhabditis elegans oocytes. Yin X, et al. Am J Physiol Cell Physiol, 2007 Jan. PMID 16899547
    3. Expression of a CIC chloride channel in Caenorhabditis elegans gamma-aminobutyric acid-ergic neurons. Bianchi L, et al. Neurosci Lett, 2001 Feb 23. PMID 11165764
    4. Into ion channel and transporter function. Caenorhabditis elegans ClC-type chloride channels: novel variants and functional expression. Nehrke K, et al. Am J Physiol Cell Physiol, 2000 Dec. PMID 11078724
    5. CLC Chloride Channels and Transporters: Structure, Function, Physiology, and Disease. Jentsch TJ, et al. Physiol Rev, 2018 Jul 1. PMID 29845874

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables voltage-gated chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables voltage-gated chloride channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chloride transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chloride transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chloride transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Chloride channel protein
    NP_001024885.1
    • Confirmed by transcript evidence
    NP_001024886.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      4094867..4100573 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001029715.3 → NP_001024886.1  Chloride channel protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024886.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L0J1, Q9BMK8
      Conserved Domains (3) summary
      cd03683
      Location:141 → 618
      ClC_1_like; ClC-1-like chloride channel proteins. This CD includes isoforms ClC-0, ClC-1, ClC-2 and ClC_K. ClC-1 is expressed in skeletal muscle and its mutation leads to both recessively and dominantly-inherited forms of muscle stiffness or myotonia. ClC-K is ...
      cd04591
      Location:888 → 945
      CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...
      pfam00654
      Location:202 → 596
      Voltage_CLC; Voltage gated chloride channel

    2. NM_001029714.2 → NP_001024885.1  Chloride channel protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024885.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95ZP4, Q9BMK8
      Conserved Domains (3) summary
      cd03683
      Location:141 → 618
      ClC_1_like; ClC-1-like chloride channel proteins. This CD includes isoforms ClC-0, ClC-1, ClC-2 and ClC_K. ClC-1 is expressed in skeletal muscle and its mutation leads to both recessively and dominantly-inherited forms of muscle stiffness or myotonia. ClC-K is ...
      cd04591
      Location:885 → 942
      CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...
      pfam00654
      Location:202 → 596
      Voltage_CLC; Voltage gated chloride channel
    Nucleotide Protein
    Heading Accession and Version

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