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    rgef-1 Ras guanyl-releasing protein 3 [ Caenorhabditis elegans ]

    Gene ID: 179344, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rgef-1
    Official Full Name
    Ras guanyl-releasing protein 3
    Primary source
    WormBase:WBGene00009100
    Locus tag
    CELE_F25B3.3
    See related
    AllianceGenome:WB:WBGene00009100
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables guanyl-nucleotide exchange factor activity. Involved in chemotaxis and positive regulation of Ras protein signal transduction. Located in cytoplasm and intracellular membrane-bounded organelle. Is expressed in excretory gland cell; nervous system; pharyngeal gland cell; rectal gland cell; and uv1. Human ortholog(s) of this gene implicated in hypertension; immunodeficiency 64; and platelet-type bleeding disorder 18. Orthologous to several human genes including RASGRP1 (RAS guanyl releasing protein 1); RASGRP2 (RAS guanyl releasing protein 2); and RASGRP3 (RAS guanyl releasing protein 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rgef-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    11
    Sequence:
    Chromosome: V; NC_003283.11 (9556027..9561674, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene EH domain-binding protein 1 Neighboring gene ncRNA Neighboring gene Serine/threonine-protein phosphatase Neighboring gene Uncharacterized protein Neighboring gene CTCK domain-containing protein Neighboring gene RNA polymerase-associated protein RTF1 homolog

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Polyglutamine proteins at the pathogenic threshold display neuron-specific aggregation in a pan-neuronal Caenorhabditis elegans model. Brignull HR, et al. J Neurosci, 2006 Jul 19. PMID 16855087, Free PMC Article
    2. A RasGRP, C. elegans RGEF-1b, couples external stimuli to behavior by activating LET-60 (Ras) in sensory neurons. Chen L, et al. Neuron, 2011 Apr 14. PMID 21482356, Free PMC Article
    3. Somatic expression of unc-54 and vha-6 mRNAs declines but not pan-neuronal rgef-1 and unc-119 expression in aging Caenorhabditis elegans. Adamla F, et al. Sci Rep, 2015 Jun 2. PMID 26031360, Free PMC Article
    4. The recurrent pathogenic Pro890Leu substitution in CLTC causes a generalized defect in synaptic transmission in Caenorhabditis elegans. Pannone L, et al. Front Mol Neurosci, 2023. PMID 37324589, Free PMC Article
    5. Lifespan extension and increased pumping rate accompany pharyngeal muscle-specific expression of nfi-1 in C. elegans. Lazakovitch E, et al. Dev Dyn, 2008 Aug. PMID 18651662

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of Ras protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Ras guanyl-releasing protein 3
    NP_001263842.1
    • Partially confirmed by transcript evidence
    NP_505469.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      9556027..9561674 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001276913.2 → NP_001263842.1  Ras guanyl-releasing protein 3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001263842.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      K8FDZ6
      Conserved Domains (4) summary
      smart00147
      Location:150 → 388
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00029
      Location:493 → 542
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:423 → 473
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam13499
      Location:427 → 477
      EF-hand_7; EF-hand domain pair

    2. NM_073068.4 → NP_505469.3  Ras guanyl-releasing protein 3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505469.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q19770
      Conserved Domains (4) summary
      smart00147
      Location:150 → 388
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00029
      Location:493 → 542
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:423 → 473
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam13499
      Location:427 → 477
      EF-hand_7; EF-hand domain pair
    Nucleotide Protein
    Heading Accession and Version

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