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    kin-26 Tyrosine-protein kinase [ Caenorhabditis elegans ]

    Gene ID: 177575, updated on 9-Dec-2024

    Summary

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    Official Symbol
    kin-26
    Official Full Name
    Tyrosine-protein kinase
    Primary source
    WormBase:WBGene00002208
    Locus tag
    CELE_T06C10.6
    See related
    AllianceGenome:WB:WBGene00002208
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein tyrosine kinase activity. Predicted to be involved in protein phosphorylation. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in esophagus squamous cell carcinoma; hepatocellular carcinoma; and lung adenocarcinoma. Orthologous to human FER (FER tyrosine kinase) and FES (FES proto-oncogene, tyrosine kinase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See kin-26 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    6
    Sequence:
    Chromosome: IV; NC_003282.8 (7875725..7877881, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene FMRF-Like Peptide Neighboring gene Tyrosine-protein kinase Neighboring gene ncRNA Neighboring gene Serpentine Receptor, class T

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sampling the genomic pool of protein tyrosine kinase genes using the polymerase chain reaction with genomic DNA. Oates AC, et al. Biochem Biophys Res Commun, 1998 Aug 28. PMID 9731193
    2. trim-21 promotes proteasomal degradation of CED-1 for apoptotic cell clearance in C. elegans. Yuan L, et al. Elife, 2022 Aug 5. PMID 35929733, Free PMC Article
    3. CEST-2.2 overexpression alters lipid metabolism and extends longevity of mitochondrial mutants. Piazzesi A, et al. EMBO Rep, 2022 May 4. PMID 35297148, Free PMC Article
    4. Genomic overview of protein kinases. Manning G. WormBook, 2005 Dec 13. PMID 18050405, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Tyrosine-protein kinase
    NP_501309.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      7875725..7877881 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068908.6 → NP_501309.1  Tyrosine-protein kinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501309.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q22245
      Conserved Domains (3) summary
      smart00219
      Location:130 → 383
      TyrKc; Tyrosine kinase, catalytic domain
      cd10361
      Location:15 → 108
      SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
      cd00192
      Location:134 → 384
      PTKc; Catalytic domain of Protein Tyrosine Kinases
    Nucleotide Protein
    Heading Accession and Version

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