sacm-1L phosphatidylinositol-3-phosphatase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: sacm-1L
Official Full Name: phosphatidylinositol-3-phosphatase
Primary source: WormBase:WBGene00009264
Locus tag: CELE_F30A10.6
See related: AllianceGenome:WB:WBGene00009264
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable phosphatidylinositol-4-phosphate phosphatase activity. Predicted to be involved in phosphatidylinositol dephosphorylation. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Is expressed in intestine; pharynx; spermatheca; and tail. Orthologous to human SACM1L (SAC1 like phosphatidylinositide phosphatase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See sacm-1L in Genome Data Viewer

Location:: chromosome: I

Exon count:: 5

Sequence:: Chromosome: I; NC_003279.8 (9488488..9492620)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Membrane contact site-dependent cholesterol transport regulates Na(+)/K(+)-ATPase polarization and spermiogenesis in Caenorhabditis elegans.
Title: Membrane contact site-dependent cholesterol transport regulates Na(+)/K(+)-ATPase polarization and spermiogenesis in Caenorhabditis elegans.
the interaction of SAC-1 with ARF-6 curbs ARF-6 activity by limiting the access of ARF-6(GDP) to its guanine nucleotide exchange factor, BRIS-1.
Title: SAC-1 ensures epithelial endocytic recycling by restricting ARF-6 activity.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F30A10.6 (e-PCR)
- UniSTS:310032

F30A10.5 (e-PCR)
- UniSTS:321417

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-4-phosphate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in phosphatidylinositol dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: phosphatidylinositol-3-phosphatase

NP_492518.2

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

9488488..9492620

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_060117.8 → NP_492518.2 phosphatidylinositol-3-phosphatase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q93641

Conserved Domains (1) summary

COG5329
Location:69 → 575

COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]