nnt-1 proton-translocating NAD(P)(+) transhydrogenase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: nnt-1
Official Full Name: proton-translocating NAD(P)(+) transhydrogenase
Primary source: WormBase:WBGene00003778
Locus tag: CELE_C15H9.1
See related: AllianceGenome:WB:WBGene00003778
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable NADP binding activity. Predicted to be involved in NADPH regeneration. Located in mitochondrion. Is expressed in coelomocyte; hypodermis; intestine; nervous system; and pharyngeal-intestinal valve. Human ortholog(s) of this gene implicated in familial glucocorticoid deficiency. Orthologous to human NNT (nicotinamide nucleotide transhydrogenase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See nnt-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 18

Sequence:: Chromosome: X; NC_003284.9 (6122311..6127554)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

evidence for expression in the gut, the pharyngeal-intestinal valve and certain neurons
Title: Expression of proton-pumping nicotinamide nucleotide transhydrogenase in mouse, human brain and C elegans.
nnt-1 is important in the defense against mitochondrial oxidative stress
Title: A Caenorhabditis elegans mutant lacking functional nicotinamide nucleotide transhydrogenase displays increased sensitivity to oxidative stress.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C15H9.1 (e-PCR)
- UniSTS:309084

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables NADP binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in NADPH regeneration	IBA Inferred from Biological aspect of Ancestor more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: proton-translocating NAD(P)(+) transhydrogenase

NP_509028.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

6122311..6127554

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_076627.6 → NP_509028.1 proton-translocating NAD(P)(+) transhydrogenase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_509028.1

Status: REVIEWED

UniProtKB/TrEMBL

Q18031

Conserved Domains (4) summary

PRK09424
Location:29 → 541

pntA; NAD(P) transhydrogenase subunit alpha; Provisional

cd05304
Location:29 → 389

Rubrum_tdh; Rubrum transdehydrogenase NAD-binding and catalytic domains

pfam02233
Location:578 → 1035

PNTB; NAD(P) transhydrogenase beta subunit

pfam12769
Location:457 → 541

PNTB_4TM; 4TM region of pyridine nucleotide transhydrogenase, mitoch