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    aspm-1 Calponin-homology (CH) domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172746, updated on 9-Dec-2024

    Summary

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    Official Symbol
    aspm-1
    Official Full Name
    Calponin-homology (CH) domain-containing protein
    Primary source
    WormBase:WBGene00008107
    Locus tag
    CELE_C45G3.1
    See related
    AllianceGenome:WB:WBGene00008107
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables calmodulin binding activity and protein domain specific binding activity. Involved in establishment of meiotic spindle orientation; meiotic spindle organization; and regulation of protein localization. Located in spindle midzone and spindle pole. Used to study microcephaly. Human ortholog(s) of this gene implicated in microcephaly; primary autosomal recessive microcephaly; primary autosomal recessive microcephaly 5; and visual epilepsy. Orthologous to human ASPM (assembly factor for spindle microtubules). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See aspm-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    8
    Sequence:
    Chromosome: I; NC_003279.8 (9221818..9226390, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Transmembrane protein Neighboring gene LIM domain protein;LIM zinc-binding domain-containing protein;Protein espinas Neighboring gene ncRNA Neighboring gene BPL/LPL catalytic domain-containing protein Neighboring gene Gamma-tubulin interacting protein 2 Neighboring gene Gamma-secretase subunit aph-1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A microcosm of the biomedical research experience for upper-level undergraduates. Hurd DD. CBE Life Sci Educ, 2008 Summer. PMID 18519612, Free PMC Article
    2. Caenorhabditis elegans oocyte meiotic spindle pole assembly requires microtubule severing and the calponin homology domain protein ASPM-1. Connolly AA, et al. Mol Biol Cell, 2014 Apr. PMID 24554763, Free PMC Article
    3. Katanin maintains meiotic metaphase chromosome alignment and spindle structure in vivo and has multiple effects on microtubules in vitro. McNally K, et al. Mol Biol Cell, 2014 Apr. PMID 24501424, Free PMC Article
    4. CDK-1 inhibits meiotic spindle shortening and dynein-dependent spindle rotation in C. elegans. Ellefson ML, et al. J Cell Biol, 2011 Jun 27. PMID 21690306, Free PMC Article
    5. ASPM is a major determinant of cerebral cortical size. Bond J, et al. Nat Genet, 2002 Oct. PMID 12355089

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. mei-1 and aspm-1 promote oocyte meiotic spindle pole assembly
      Title: Caenorhabditis elegans oocyte meiotic spindle pole assembly requires microtubule severing and the calponin homology domain protein ASPM-1.
    2. ASPM-1, together with calmodulin (CMD-1), promotes meiotic spindle organization and the accumulation of LIN-5 at meiotic and mitotic spindle poles.
      Title: NuMA-related LIN-5, ASPM-1, calmodulin and dynein promote meiotic spindle rotation independently of cortical LIN-5/GPR/Galpha.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in establishment of meiotic spindle localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment of meiotic spindle orientation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in establishment of meiotic spindle orientation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle midzone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle pole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Calponin-homology (CH) domain-containing protein
    NP_492467.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      9221818..9226390 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060066.6 → NP_492467.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492467.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O17666
      Conserved Domains (2) summary
      smart00015
      Location:959 → 980
      IQ; Calmodulin-binding motif
      smart00033
      Location:353 → 433
      CH; Calponin homology domain
    Nucleotide Protein
    Heading Accession and Version

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