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    ucr-1 Cytochrome b-c1 complex subunit 1, mitochondrial;Peptidase M16 C-terminal domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 175772, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ucr-1
    Official Full Name
    Cytochrome b-c1 complex subunit 1, mitochondrial;Peptidase M16 C-terminal domain-containing protein
    Primary source
    WormBase:WBGene00018963
    Locus tag
    CELE_F56D2.1
    See related
    AllianceGenome:WB:WBGene00018963
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable metal ion binding activity. Located in mitochondrion. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human UQCRC1 (ubiquinol-cytochrome c reductase core protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ucr-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    10
    Sequence:
    Chromosome: III; NC_003281.10 (5592135..5594401)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene DUF148 domain-containing protein Neighboring gene RBR-type E3 ubiquitin transferase Neighboring gene Pre-mRNA-splicing factor ATP-dependent RNA helicase ddx-15;RNA helicase Neighboring gene ncRNA Neighboring gene Cell death protein 6 Neighboring gene WD repeat-containing protein 37

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and reverse genetic analysis of mitochondrial processing peptidase and the core protein of the cytochrome bc1 complex of Caenorhabditis elegans, a model parasitic nematode. Nomura H, et al. J Biochem, 2006 Jun. PMID 16788047
    2. Mitochondrial modulation of phosphine toxicity and resistance in Caenorhabditis elegans. Zuryn S, et al. Toxicol Sci, 2008 Mar. PMID 17998274
    3. Analysis of acidic peptides with a matrix-assisted laser desorption/ionization mass spectrometry using positive and negative ion modes with additive monoammonium phosphate. Nabetani T, et al. Proteomics, 2006 Aug. PMID 16897684
    4. Mitochondrial protein import determines lifespan through metabolic reprogramming and de novo serine biosynthesis. Lionaki E, et al. Nat Commun, 2022 Feb 3. PMID 35115503, Free PMC Article
    5. Galectin LEC-1 plays a defensive role against damage due to oxidative stress in Caenorhabditis elegans. Takeuchi T, et al. J Biochem, 2013 Nov. PMID 23935187

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of respiratory chain complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cytochrome b-c1 complex subunit 1, mitochondrial;Peptidase M16 C-terminal domain-containing protein
    NP_001343795.1
    • Confirmed by transcript evidence
    NP_001368666.1
    • Confirmed by transcript evidence
    NP_001368667.1
    • Confirmed by transcript evidence
    NP_498202.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      5592135..5594401
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065801.8 → NP_498202.1  Cytochrome b-c1 complex subunit 1, mitochondrial [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498202.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P98080
      Conserved Domains (3) summary
      COG0612
      Location:30 → 460
      PqqL; Predicted Zn-dependent peptidase [General function prediction only]
      pfam00675
      Location:48 → 195
      Peptidase_M16; Insulinase (Peptidase family M16)
      pfam05193
      Location:200 → 386
      Peptidase_M16_C; Peptidase M16 inactive domain

    2. NM_001356762.4 → NP_001343795.1  Cytochrome b-c1 complex subunit 1, mitochondrial [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2C9C3L5
      Conserved Domains (1) summary
      COG0612
      Location:30 → 462
      PqqL; Predicted Zn-dependent peptidase [General function prediction only]

    3. NM_001379716.1 → NP_001368667.1  Peptidase M16 C-terminal domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2C9C3F6
      Conserved Domains (1) summary
      COG0612
      Location:1 → 287
      PqqL; Predicted Zn-dependent peptidase [General function prediction only]

    4. NM_001379717.1 → NP_001368666.1  Peptidase M16 C-terminal domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2C9C366
      Conserved Domains (1) summary
      COG0612
      Location:1 → 285
      PqqL; Predicted Zn-dependent peptidase [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P98080.2

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