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    H2-Eb1 histocompatibility 2, class II antigen E beta [ Mus musculus (house mouse) ]

    Gene ID: 14969, updated on 9-Dec-2024

    Summary

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    Official Symbol
    H2-Eb1provided by MGI
    Official Full Name
    histocompatibility 2, class II antigen E betaprovided by MGI
    Primary source
    MGI:MGI:95901
    See related
    Ensembl:ENSMUSG00000060586 AllianceGenome:MGI:95901
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Eb; Ia4; H2Eb; Ia-4; H-2Eb
    Summary
    Predicted to enable several functions, including MHC class II receptor activity; peptide antigen binding activity; and signaling receptor binding activity. Acts upstream of or within antigen processing and presentation of exogenous peptide antigen via MHC class II. Predicted to be located in external side of plasma membrane and immunological synapse. Predicted to be part of MHC class II protein complex. Predicted to be active in late endosome membrane and lysosomal membrane. Is expressed in lung. Human ortholog(s) of this gene implicated in several diseases, including asthma (multiple); autoimmune disease (multiple); bacterial infectious disease (multiple); eye disease (multiple); and sarcoidosis (multiple). Orthologous to several human genes including HLA-DRB5 (major histocompatibility complex, class II, DR beta 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in spleen adult (RPKM 375.3), large intestine adult (RPKM 229.1) and 12 other tissues See more
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    Genomic context

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    See H2-Eb1 in Genome Data Viewer
    Location:
    17 B1; 17 17.98 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34524841..34535648)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34305867..34316674)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8669 Neighboring gene histocompatibility 2, class II antigen A, beta 1 Neighboring gene STARR-positive B cell enhancer ABC_E1194 Neighboring gene histocompatibility 2, class II antigen A, alpha Neighboring gene STARR-positive B cell enhancer ABC_E2485 Neighboring gene STARR-positive B cell enhancer ABC_E397 Neighboring gene STARR-positive B cell enhancer ABC_E1505 Neighboring gene STARR-positive B cell enhancer ABC_E1940 Neighboring gene STARR-positive B cell enhancer ABC_E957 Neighboring gene STARR-seq mESC enhancer starr_42428 Neighboring gene STARR-positive B cell enhancer ABC_E8670 Neighboring gene STARR-positive B cell enhancer ABC_E8919 Neighboring gene histocompatibility 2, class II antigen E beta2 Neighboring gene STARR-seq mESC enhancer starr_42429 Neighboring gene histocompatibility 2, class II antigen E alpha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Sequence analysis of MHC class II Eb cDNAs from H2r and H2p haplotypes. Wei BY, et al. Immunogenetics, 1996. PMID 8662092
    2. A new I subregion (I-J) marked by a locus (Ia-4) controlling surface determinants on suppressor T lymphocytes. Murphy DB, et al. J Exp Med, 1976 Sep 1. PMID 1085338, Free PMC Article
    3. Multiple sites of crossing over within the Eb recombinational hotspot in the mouse. Bryda EC, et al. Mamm Genome, 1992. PMID 1347471
    4. Interaction of H-2Eb with an IAP retrotransposon in the A20/2J B cell lymphoma. Malstrom CE, et al. Immunogenetics, 1992. PMID 1353478
    5. Structural and genetic properties of the Eb recombinational hotspot in the mouse. Zimmerer EJ, et al. Immunogenetics, 1991. PMID 1847899

    See all (85) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. may play an important role in regulating Th1/Th2 balance during the pathogenesis of allergic rhinitis
      Title: H2-EB1 Molecule Alleviates Allergic Rhinitis Symptoms of H2-Eb1 Knockout Mice.
    2. Evidence that MHC I-E dampens thyroid autoantibodies and prevents spreading to a second thyroid autoantigen in I-A(k) NOD mice.
      Title: Evidence that MHC I-E dampens thyroid autoantibodies and prevents spreading to a second thyroid autoantigen in I-A(k) NOD mice.
    3. H2-Eb1 expression was significantly upregulated in the nasal mucosa of our successfully established allergic rhinitis mouse model
      Title: H2-Eb1 expression is upregulated in the nasal mucosa of allergic rhinitis.
    4. Data demonstrate that the presence of distinct forms of MHC-II with plasma membrane lipid rafts is required for MHC-II aggregation in APCs.
      Title: Distinct MHC class II molecules are associated on the dendritic cell surface in cholesterol-dependent membrane microdomains.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (7) 
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC163794, MGC163796

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables CD4 receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables MHC class II protein complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables MHC class II receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables T cell receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptide antigen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide antigen binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables polysaccharide binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within antigen processing and presentation of exogenous peptide antigen via MHC class II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in peptide antigen assembly with MHC class II protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of T cell activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of MHC class II protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MHC class II protein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in immunological synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in late endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in late endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    H-2 class II histocompatibility antigen, I-E beta chain
    Names
    I-E beta MHC class II
    MHC H2-IE-beta cell surface glycoprotein
    MHC class II IE-b
    cell surface glycoprotein
    histocompatibility 2, class II antigen E beta, promoter 1
    major histocompatibility complex H-2E beta chain

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010382.2 → NP_034512.2  H-2 class II histocompatibility antigen, I-E beta chain precursor

      See identical proteins and their annotated locations for NP_034512.2

      Status: VALIDATED

      Source sequence(s)
      AK160485, BY202562, CAAA01111730
      Consensus CDS
      CCDS37584.1
      UniProtKB/Swiss-Prot
      O78226, P04230
      UniProtKB/TrEMBL
      F6VX29, O78196
      Related
      ENSMUSP00000158533.2, ENSMUST00000235530.2
      Conserved Domains (2) summary
      pfam00969
      Location:40 → 114
      MHC_II_beta; Class II histocompatibility antigen, beta domain
      cl11960
      Location:124 → 217
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      34524841..34535648
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P04230.1 GenPept UniProtKB/Swiss-Prot:P04230
    P04231.1 GenPept UniProtKB/Swiss-Prot:P04231
    P18468.1 GenPept UniProtKB/Swiss-Prot:P18468
    P18469.1 GenPept UniProtKB/Swiss-Prot:P18469
    P20040.1 GenPept UniProtKB/Swiss-Prot:P20040

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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