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    Kcna3 potassium voltage-gated channel, shaker-related subfamily, member 3 [ Mus musculus (house mouse) ]

    Gene ID: 16491, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kcna3provided by MGI
    Official Full Name
    potassium voltage-gated channel, shaker-related subfamily, member 3provided by MGI
    Primary source
    MGI:MGI:96660
    See related
    Ensembl:ENSMUSG00000047959 AllianceGenome:MGI:96660
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mk-3; Kv1.3; Kca1-3
    Summary
    Enables voltage-gated potassium channel activity. Predicted to be involved in action potential and potassium ion transmembrane transport. Located in axon and plasma membrane. Is expressed in brain and heart. Orthologous to human KCNA3 (potassium voltage-gated channel subfamily A member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human all
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    Genomic context

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    See Kcna3 in Genome Data Viewer
    Location:
    3 F2.3; 3 46.59 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (106943486..106947223)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (107036162..107038129)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 18162 Neighboring gene predicted gene, 27008 Neighboring gene STARR-seq mESC enhancer starr_08657 Neighboring gene STARR-seq mESC enhancer starr_08658 Neighboring gene STARR-positive B cell enhancer ABC_E826 Neighboring gene STARR-positive B cell enhancer ABC_E7936 Neighboring gene expressed sequence AI504432 Neighboring gene predicted gene, 38712 Neighboring gene STARR-positive B cell enhancer ABC_E4573 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:106883731-106883985 Neighboring gene STARR-positive B cell enhancer ABC_E7937 Neighboring gene potassium voltage-gated channel, shaker-related subfamily, member 2 Neighboring gene potassium voltage-gated channel, shaker-related subfamily, member 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Kv1.3 deletion biases T cells toward an immunoregulatory phenotype and renders mice resistant to autoimmune encephalomyelitis. Gocke AR, et al. J Immunol, 2012 Jun 15. PMID 22581856, Free PMC Article
    2. Compensatory anion currents in Kv1.3 channel-deficient thymocytes. Koni PA, et al. J Biol Chem, 2003 Oct 10. PMID 12878608
    3. Mitochondrial Ultrastructure and Glucose Signaling Pathways Attributed to the Kv1.3 Ion Channel. Kovach CP, et al. Front Physiol, 2016. PMID 27242550, Free PMC Article
    4. Kv1.3 channel blockade enhances the phagocytic function of RAW264.7 macrophages. Zhu H, et al. Sci China Life Sci, 2015 Sep. PMID 26354506
    5. Antigenic Stimulation of Kv1.3-Deficient Th Cells Gives Rise to a Population of Foxp3-Independent T Cells with Suppressive Properties. Grishkan IV, et al. J Immunol, 2015 Aug 15. PMID 26150529, Free PMC Article

    See all (95) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Kv1.3 mediates ox-LDL-induced vascular smooth muscle cell proliferation through JAK2/STAT3 signaling pathway.
      Title: Kv1.3 mediates ox-LDL-induced vascular smooth muscle cell proliferation through JAK2/STAT3 signaling pathway.
    2. Kv1.3 Channel Is Involved In Ox-LDL-induced Macrophage Inflammation Via ERK/NF-kappaB signaling pathway.
      Title: Kv1.3 Channel Is Involved In Ox-LDL-induced Macrophage Inflammation Via ERK/NF-κB signaling pathway.
    3. The voltage-gated potassium channel KV1.3 regulates neutrophil recruitment during inflammation.
      Title: The voltage-gated potassium channel KV1.3 regulates neutrophil recruitment during inflammation.
    4. Unique molecular characteristics and microglial origin of Kv1.3 channel-positive brain myeloid cells in Alzheimer's disease.
      Title: Unique molecular characteristics and microglial origin of Kv1.3 channel-positive brain myeloid cells in Alzheimer's disease.
    5. The Kv1.3 ion channel acts as a host factor restricting viral entry.
      Title: The Kv1.3 ion channel acts as a host factor restricting viral entry.
    6. Potassium Channels Kv1.3 and Kir2.1 But Not Kv1.5 Contribute to BV2 Cell Line and Primary Microglial Migration.
      Title: Potassium Channels Kv1.3 and Kir2.1 But Not Kv1.5 Contribute to BV2 Cell Line and Primary Microglial Migration.
    7. Kv1.3 modulates neuroinflammation and neurodegeneration in Parkinson's disease.
      Title: Kv1.3 modulates neuroinflammation and neurodegeneration in Parkinson's disease.
    8. Luteolin-mediated Kv1.3 K+ channel inhibition augments BCG vaccine efficacy against tuberculosis by promoting central memory T cell responses in mice.
      Title: Luteolin-mediated Kv1.3 K+ channel inhibition augments BCG vaccine efficacy against tuberculosis by promoting central memory T cell responses in mice.
    9. beta1-Integrin- and KV1.3 channel-dependent signaling stimulates glutamate release from Th17 cells.
      Title: β1-Integrin- and KV1.3 channel-dependent signaling stimulates glutamate release from Th17 cells.
    10. Long-term obesogenic diet and targeted deletion of potassium channel Kv 1.3 have differing effects on voluntary exercise in mice.
      Title: Long-term obesogenic diet and targeted deletion of potassium channel K(v) 1.3 have differing effects on voluntary exercise in mice.
    Submit: New GeneRIF Correction See all GeneRIFs (57)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables delayed rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables delayed rectifier potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables delayed rectifier potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables outward rectifier potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables outward rectifier potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables voltage-gated potassium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables voltage-gated potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in corpus callosum development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in optic nerve development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in calyx of Held IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in calyx of Held ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane raft IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in presynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated potassium channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    potassium voltage-gated channel subfamily A member 3
    Names
    MK3
    Voltage-gated potassium channel protein Kv1.3 (RGK5) (RCK3) (KV3)
    voltage-gated potassium channel subunit Kv1.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008418.3 → NP_032444.2  potassium voltage-gated channel subfamily A member 3

      See identical proteins and their annotated locations for NP_032444.2

      Status: VALIDATED

      Source sequence(s)
      AC121825
      Consensus CDS
      CCDS17730.1
      UniProtKB/Swiss-Prot
      A3KMM2, P16390
      Related
      ENSMUSP00000050680.4, ENSMUST00000052718.5
      Conserved Domains (4) summary
      smart00225
      Location:59 → 153
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00520
      Location:243 → 443
      Ion_trans; Ion transport protein
      pfam02214
      Location:59 → 150
      BTB_2; BTB/POZ domain
      pfam07885
      Location:357 → 434
      Ion_trans_2; Ion channel

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      106943486..106947223
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P16390.3 GenPept UniProtKB/Swiss-Prot:P16390

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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