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    Usp34 ubiquitin specific peptidase 34 [ Mus musculus (house mouse) ]

    Gene ID: 17847, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Usp34provided by MGI
    Official Full Name
    ubiquitin specific peptidase 34provided by MGI
    Primary source
    MGI:MGI:109473
    See related
    Ensembl:ENSMUSG00000056342 AllianceGenome:MGI:109473
    Gene type
    protein coding
    RefSeq status
    INFERRED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Murr2; A530081C03Rik
    Summary
    Predicted to enable cysteine-type deubiquitinase activity and cysteine-type endopeptidase activity. Predicted to be involved in positive regulation of canonical Wnt signaling pathway; protein K48-linked deubiquitination; and regulation of protein stability. Predicted to be active in cytosol and nucleus. Orthologous to human USP34 (ubiquitin specific peptidase 34). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 12.8), CNS E14 (RPKM 10.9) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Usp34 in Genome Data Viewer
    Location:
    11 A3.2; 11 14.29 cM
    Exon count:
    80
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (23256433..23440560)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (23303185..23490560)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_28906 Neighboring gene predicted gene, 24398 Neighboring gene STARR-seq mESC enhancer starr_28907 Neighboring gene STARR-seq mESC enhancer starr_28908 Neighboring gene STARR-positive B cell enhancer ABC_E729 Neighboring gene exportin 1 Neighboring gene STARR-seq mESC enhancer starr_28911 Neighboring gene RIKEN cDNA 1700030C12 gene Neighboring gene STARR-positive B cell enhancer ABC_E9818 Neighboring gene predicted gene, 22753 Neighboring gene STARR-seq mESC enhancer starr_28912 Neighboring gene RIKEN cDNA 1700093K21 gene Neighboring gene STARR-seq mESC enhancer starr_28914 Neighboring gene STARR-seq mESC enhancer starr_28915 Neighboring gene AHA1, activator of heat shock protein ATPase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Inhibition of ubiquitin-specific protease 34 (USP34) induces epithelial-mesenchymal transition and promotes stemness in mammary epithelial cells. Oh E, et al. Cell Signal, 2017 Aug. PMID 28499884
    2. Ubiquitin-Specific Protease 34 Inhibits Osteoclast Differentiation by Regulating NF-κB Signaling. Li Q, et al. J Bone Miner Res, 2020 Aug. PMID 32212276
    3. Protein phosphorylation and expression profiling by Yin-yang multidimensional liquid chromatography (Yin-yang MDLC) mass spectrometry. Dai J, et al. J Proteome Res, 2007 Jan. PMID 17203969
    4. Ubiquitin-specific protease USP34 controls osteogenic differentiation and bone formation by regulating BMP2 signaling. Guo YC, et al. EMBO J, 2018 Oct 15. PMID 30181118, Free PMC Article
    5. Mouse U2af1-rs1 is a neomorphic imprinted gene. Nabetani A, et al. Mol Cell Biol, 1997 Feb. PMID 9001233, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ubiquitin-Specific Protease 34 Inhibits Osteoclast Differentiation by Regulating NF-kappaB Signaling.
      Title: Ubiquitin-Specific Protease 34 Inhibits Osteoclast Differentiation by Regulating NF-κB Signaling.
    2. data indicate that USP34 is required for osteogenic differentiation and bone formation.
      Title: Ubiquitin-specific protease USP34 controls osteogenic differentiation and bone formation by regulating BMP2 signaling.
    3. the role of USP34 on epithelial-mesenchymal (EMT) induction and its effects on mammary epithelial stem cells, was investigated.
      Title: Inhibition of ubiquitin-specific protease 34 (USP34) induces epithelial-mesenchymal transition and promotes stemness in mammary epithelial cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3)  1 citation
    • Gene trapped (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cysteine-type deubiquitinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cysteine-type endopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein K48-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K48-linked deubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein stability IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 34
    Names
    U2af1-rs1 region 2
    deubiquitinating enzyme 34
    ubiquitin specific protease 34
    ubiquitin thioesterase 34
    ubiquitin thiolesterase 34
    ubiquitin-specific-processing protease 34
    NP_001177330.2
    XP_006514628.1
    XP_006514629.1
    XP_006514630.1
    XP_017169806.1
    XP_030101492.1
    XP_030101493.1
    XP_036012290.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001190401.2 → NP_001177330.2  ubiquitin carboxyl-terminal hydrolase 34

      See identical proteins and their annotated locations for NP_001177330.2

      Status: INFERRED

      Source sequence(s)
      AL672004, AL672049, AL772359, AL928722
      Consensus CDS
      CCDS56763.1
      UniProtKB/Swiss-Prot
      A2AF26, A2AF27, A2AF77, Q3UF93, Q3UPN0, Q6P563, Q6ZQ93, Q7TMJ6, Q8CCH0
      UniProtKB/TrEMBL
      F6WJB7
      Related
      ENSMUSP00000137430.2, ENSMUST00000180046.8
      Conserved Domains (2) summary
      cd02659
      Location:1929 → 2278
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:1931 → 2273
      UCH; Ubiquitin carboxyl-terminal hydrolase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      23256433..23440560
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514566.4 → XP_006514629.1  ubiquitin carboxyl-terminal hydrolase 34 isoform X2

      UniProtKB/TrEMBL
      F6WJB7
      Conserved Domains (1) summary
      cd02659
      Location:1918 → 2267
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

    2. XM_006514565.3 → XP_006514628.1  ubiquitin carboxyl-terminal hydrolase 34 isoform X1

      UniProtKB/TrEMBL
      F6WJB7
      Conserved Domains (1) summary
      cd02659
      Location:1930 → 2279
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

    3. XM_006514567.3 → XP_006514630.1  ubiquitin carboxyl-terminal hydrolase 34 isoform X4

      UniProtKB/TrEMBL
      F6WJB7
      Conserved Domains (1) summary
      cd02659
      Location:1930 → 2279
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

    4. XM_017314317.3 → XP_017169806.1  ubiquitin carboxyl-terminal hydrolase 34 isoform X5

      UniProtKB/TrEMBL
      F6WJB7
      Conserved Domains (1) summary
      cd02659
      Location:1929 → 2278
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

    5. XM_036156397.1 → XP_036012290.1  ubiquitin carboxyl-terminal hydrolase 34 isoform X3

      UniProtKB/TrEMBL
      F6WJB7
      Conserved Domains (2) summary
      cd02659
      Location:1892 → 2241
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam12030
      Location:2359 → 2692
      DUF3517; Domain of unknown function (DUF3517)

    6. XM_030245632.2 → XP_030101492.1  ubiquitin carboxyl-terminal hydrolase 34 isoform X6

      UniProtKB/TrEMBL
      F6WJB7
      Conserved Domains (1) summary
      cd02659
      Location:1731 → 2080
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

    7. XM_030245633.2 → XP_030101493.1  ubiquitin carboxyl-terminal hydrolase 34 isoform X7

      UniProtKB/TrEMBL
      F6WJB7
      Conserved Domains (1) summary
      cd02659
      Location:1719 → 2068
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZQ93.3 GenPept UniProtKB/Swiss-Prot:Q6ZQ93

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