Trem1 triggering receptor expressed on myeloid cells 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Trem1provided by RGD
Official Full Name: triggering receptor expressed on myeloid cells 1provided by RGD
Primary source: RGD:1309467
See related: EnsemblRapid:ENSRNOG00000022859 AllianceGenome:RGD:1309467
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable receptor decoy activity; scaffold protein binding activity; and transmembrane signaling receptor activity. Involved in several processes, including cellular response to lipopolysaccharide; cellular response to vitamin D; and positive regulation of macrophage chemotaxis. Predicted to be located in plasma membrane. Predicted to be active in cell surface and extracellular space. Used to study several diseases, including acute pancreatitis; bacterial sepsis; mesenteric vascular occlusion; middle cerebral artery infarction; and pleural empyema. Biomarker of congestive heart failure; depressive disorder; periodontitis; and rheumatoid arthritis. Human ortholog(s) of this gene implicated in bacterial sepsis and malaria. Orthologous to human TREM1 (triggering receptor expressed on myeloid cells 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 22.7), Spleen (RPKM 8.9) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q12

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (20259227..20276879, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (12763819..12779285, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (14727887..14743371, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Role of TREM-1 in the development of early brain injury after subarachnoid hemorrhage.
Title: Role of TREM-1 in the development of early brain injury after subarachnoid hemorrhage.
TREM1 may be involved in the pathogenesis of experimental autoimmune neuritis (EAN), and that inhibition of TREM-1 may ameliorate EAN.
Title: Inhibition of triggering receptor expressed on myeloid cells-1 ameliorates experimental autoimmune neuritis.
TREM-1 might be an important mediator post coxsackievirus B3 infection and a major player on inducing excess macrophage-related inflammation, resulting in an indirect injury to cardiomyocytes.
Title: [Role of triggering receptor expressed on myeloid cells-1 on coxsackievirus B3-induced inflammation and cardiomyocyte injury].
TREM-1 may act as an important mediator for inflammation and organ injury in severe acute pancreatitis.
Title: Role of triggering receptor expressed on myeloid cells-1 in experimental severe acute pancreatitis.
TREM 1 has a role in pathway modulation during hemorrhagic shock in rats
Title: Effects of the TREM 1 pathway modulation during hemorrhagic shock in rats.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables receptor decoy activity	ISO Inferred from Sequence Orthology more info
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info
enables transmembrane signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane signaling receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in cellular response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to vitamin D	IEP Inferred from Expression Pattern more info	PubMed
involved_in cytokine production involved in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in neutrophil chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neutrophil chemotaxis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neutrophil extravasation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neutrophil migration	ISO Inferred from Sequence Orthology more info
involved_in neutrophil-mediated killing of gram-negative bacterium	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neutrophil-mediated killing of gram-negative bacterium	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell-matrix adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell-matrix adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of macrophage chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of macrophage chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: triggering receptor expressed on myeloid cells 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106885.1 → NP_001100355.1 triggering receptor expressed on myeloid cells 1

See identical proteins and their annotated locations for NP_001100355.1

Status: PROVISIONAL

Source sequence(s)

CH473987

UniProtKB/TrEMBL

A6JIG5

Conserved Domains (1) summary

cl11960
Location:1 → 89

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

20259227..20276879 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039083174.2 → XP_038939102.1 triggering receptor expressed on myeloid cells 1 isoform X1

UniProtKB/TrEMBL

D4ABU7

Related

ENSRNOP00000040482.4, ENSRNOT00000049193.6

Conserved Domains (2) summary

cd00096
Location:28 → 33

Ig; Ig strand A' [structural motif]

cl11960
Location:24 → 132

Ig; Immunoglobulin domain