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    Ppp6r1 protein phosphatase 6, regulatory subunit 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361502, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ppp6r1provided by RGD
    Official Full Name
    protein phosphatase 6, regulatory subunit 1provided by RGD
    Primary source
    RGD:1311409
    See related
    EnsemblRapid:ENSRNOG00000018090 AllianceGenome:RGD:1311409
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Saps1; RGD1311409
    Summary
    Predicted to enable protein phosphatase regulator activity and small GTPase binding activity. Predicted to be involved in regulation of signal transduction. Predicted to be active in cytosol and nucleus. Orthologous to human PPP6R1 (protein phosphatase 6 regulatory subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 267.8), Spleen (RPKM 219.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ppp6r1 in Genome Data Viewer
    Location:
    1q12
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (78218629..78246360)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (69190856..69217598)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (72756819..72784492)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene BR serine/threonine kinase 1 Neighboring gene uncharacterized LOC108349434 Neighboring gene HSPA (Hsp70) binding protein 1 Neighboring gene transmembrane protein 86B Neighboring gene protein tyrosine phosphatase, receptor type, H Neighboring gene uncharacterized LOC108349515

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Role of the Rho GTPase-activating protein RICS in neurite outgrowth. Nasu-Nishimura Y, et al. Genes Cells, 2006 Jun. PMID 16716191
    2. CCM-3/STRIPAK promotes seamless tube extension through endocytic recycling. Lant B, et al. Nat Commun, 2015 Mar 6. PMID 25743393
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein phosphatase regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein phosphatase 6 regulatory subunit 1
    Names
    SAPS domain family, member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135849.2 → NP_001129321.1  serine/threonine-protein phosphatase 6 regulatory subunit 1

      See identical proteins and their annotated locations for NP_001129321.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6KNM6
      Related
      ENSRNOP00000101673.1, ENSRNOT00000127951.1
      Conserved Domains (2) summary
      pfam04499
      Location:128 → 519
      SAPS; SIT4 phosphatase-associated protein
      pfam06121
      Location:715 → 811
      DUF959; Domain of Unknown Function (DUF959)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      78218629..78246360
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063266286.1 → XP_063122356.1  serine/threonine-protein phosphatase 6 regulatory subunit 1 isoform X1

      Related
      ENSRNOP00000106703.1, ENSRNOT00000156853.1

    2. XM_063266288.1 → XP_063122358.1  serine/threonine-protein phosphatase 6 regulatory subunit 1 isoform X2

    3. XM_063266289.1 → XP_063122359.1  serine/threonine-protein phosphatase 6 regulatory subunit 1 isoform X3

      Related
      ENSRNOP00000112167.1, ENSRNOT00000082423.3
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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